Characteristic features of pulmonary function test, CT volume analysis and MR perfusion imaging in COPD patients with different HRCT phenotypes
Characteristic features of pulmonary function test, CT volume analysis and MR perfusion imaging in COPD patients with different HRCT phenotypes
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不同HRCT表型的COPD患者肺功能检查、CT容积分析和MR灌注成像的特征。
DOI：
10.1111/crj.12033
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发表时间：
2014-01-01
影响因子：
1.7
通讯作者：
Liu, Shi-yuan
中科院分区：
文献类型：
--
作者：
Fan, Li;Xia, Yi;Liu, Shi-yuan
前言计算机断层扫描（CT）和磁共振成像（MRI）能为慢性阻塞性肺疾病（COPD）提供详细的解剖结构和定量的肺功能信息。不同高分辨率计算机断层扫描（HRCT）表型的COPD患者的CT容积参数和磁共振（MR）灌注成像。2例患者行PFT、CT和MR灌注成像。根据HRCT定量结果将COPD分为三种表型：A型、E型和M型。用HRCT定量肺总体积（TLV）、肺气肿总体积（TEV）和肺气肿指数（EI）。在灌注缺损（PD）的情况下，对形状和大小进行评价。通过计算它们的信号强度比（R-SI=SIPD/SInormal）来量化正常肺与PD之间的对比。结果A型42例，E型9例，M型11例。A型与M型之间FEV 1/FVC差异有显著性（P
IntroductionComputed tomography (CT) and magnetic resonance imaging (MRI) can provide detailed anatomic structures and quantitative function information for chronic obstructive pulmonary disease (COPD).ObjectivesTo prospectively clarify characteristics of pulmonary function test (PFT), CT volume parameters and magnetic resonance (MR) perfusion imaging in COPD patients with different high-resolution computed tomography (HRCT) phenotypes.Methods Sixty-two patients performed PFT, CT and MR perfusion imaging. COPD was classified into three phenotypes according to HRCT quantitative findings: A, E and M phenotype. Total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were quantitated by HRCT. In cases of perfusion defects (PDs), the shape and size were evaluated. The contrast between the normal lung and PDs was quantified by calculating their signal intensity ratio (R-SI=SIPD/SInormal). The correlation was performed between PFT, CT and MR perfusion.ResultsThere were 42 A phenotype, 9 E phenotype and 11 M phenotype. There was significant difference in forced expiratory volume in 1s (FEV1)/forced vital capacity (FVC) between A and M phenotype (P