Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.
Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.
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DOI：
10.1289/ehp.02110s3409
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发表时间：
2002-06
影响因子：
10.4
通讯作者：
Dessi-Fulgheri, Francesco
中科院分区：
文献类型：
--
作者：
Farabollini, Francesca;Porrini, Stefania;Della Seta, Daniele;Bianchi, Fiorella;Dessi-Fulgheri, Francesco
雌激素或芳香化类固醇在中枢神经系统水平的围产期作用是脑性别分化的原因。通过与中枢神经系统的早期接触，雌激素化合物双酚A（BPA）可以改变影响社会性行为的过程。为了验证这一假设，我们研究了成年雌性和雄性大鼠的激动和性行为，这些大鼠的母亲在怀孕或哺乳期间被给予BPA（40 μ g/kg/天）。入侵者测试显示，在男性，但不是在女性的防御行为增加，由于双酚A。我们通过测试性取向和性活动来研究BPA对性行为的影响。男性对刺激女性的性取向不受BPA的影响，而性活动测试显示，由于BPA的潜伏期和频率的导入性行为轻微受损。在女性中，BPA使性动机和接受行为略有增加。总之，BPA管理，无论是在怀孕期间和哺乳期间，不男性化的女性行为或增强男性的男性化过程。相反，我们观察到的增强女性的女性行为和男性的男性行为的去增强。
Perinatal action of estrogens or aromatizable steroids at the central nervous system level is responsible for brain sexual differentiation. Through early contact with the central nervous system, the estrogenic compound bisphenol A (BPA) could alter the processes affecting sociosexual behavior. To test this hypothesis, we studied agonistic and sexual behavior of adult female and male rats whose mothers were administered BPA (40 microg/kg/day) during pregnancy or lactation. An intruder test revealed in males but not in females an increase in defensive behavior due to BPA. We studied the effect of BPA on sexual behavior by testing sexual orientation and sexual activity. Male sexual orientation toward a stimulus female was not affected by BPA, whereas the sexual activity test revealed a slight impairment of sexual performance due to BPA in terms of latency and frequency of intromissions. In females, BPA produced a small increase in sexual motivation and receptive behavior. In conclusion, BPA administration, both during pregnancy and during lactation, does not masculinize female behavior or potentiate masculinization processes of males. On the contrary, we observed a potentiation of female behavior in females and a depotentiation of male behavior in males.