Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys
Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys
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DOI：
10.1016/j.neurobiolaging.2022.01.007
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发表时间：
2022-03-10
影响因子：
4.2
通讯作者：
Hahn, Caroline
中科院分区：
文献类型：
--
作者：
Malbon, Alexandra J.;Sordo, Lorena;Hahn, Caroline
神经退行性疾病在动物和人的老龄化群体中越来越重要。改变的胰岛素信号传导和II型糖尿病与人类阿尔茨海默病（AD）的发展和其他长寿动物的AD样神经变性有关。驴在家养物种中是不寻常的，因为它们的寿命特别长，而且还容易发生与人类相似的胰岛素代谢异常。在这项研究中，对13头老年驴（> 30岁）和2头年轻对照驴的顶叶和海马进行了免疫组织学评估，以确定神经元缠结（NFT）和淀粉样斑块（AP）的存在、分布和频率; AD的特征性病变。AP在9头驴的顶叶皮质中，偏好于深沟，在7头驴中观察到NFT样结构，主要在皮质区域内。在对照驴中未观察到变化。这代表了第一次确定的AP和NFT在马科动物，是一个刺激，为未来的工作评估其代谢状态的平行。(c)2022爱思唯尔公司All rights reserved.
Neurodegenerative disorders are gaining ever more importance in ageing populations of animals and people. Altered insulin signaling and type II diabetes have been linked to the development of Alzheimer's disease (AD) in humans and AD-like neurodegeneration in other long-lived animals. Donkeys are unusual amongst domestic species for their exceptional longevity and are additionally predisposed to abnormalities of insulin metabolism similar to those found in humans. In this study, the parietal lobe and hippocampus of 13 aged ( > 30 years) and 2 younger control donkeys were evaluated immunohistologically for the presence, distribution, and frequency of neurofibrillary tangles (NFT) and amyloid plaques (AP); the characteristic lesions of AD. AP were in parietal cortices of 9 donkeys, with a predilection for deep sulci, and NFT-like structures were observed in 7 donkeys, primarily within cortical areas. No changes were observed in the control donkeys. This represents the first identification of both AP and NFT in equids and is a stimulus for future work assessing their metabolic status in parallel.(c) 2022 Elsevier Inc. All rights reserved.