REVERSE CHOLESTEROL TRANSPORT WITH ACUTE EXERCISE
REVERSE CHOLESTEROL TRANSPORT WITH ACUTE EXERCISE
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DOI：
10.1249/00005768-199312000-00005
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发表时间：
1993-12-01
期刊：
影响因子：
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通讯作者：
RYMASZEWSKI, ZJ
中科院分区：
文献类型：
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作者：
CAMPAIGNE, BN;FONTAINE, RN;RYMASZEWSKI, ZJ
身体活动已被证明与冠心病（CHD）呈负相关。高密度脂蛋白（HDL）颗粒在胆固醇逆向转运过程中的作用可能是运动与冠心病预防之间的桥梁。本研究的目的是评估急性运动对人单核细胞衍生的巨噬细胞胆固醇流出（C-EF）的影响，该巨噬细胞胆固醇超载，随后与从血浆中分离的HDL组分一起孵育。10名男性; 5名久坐者（NR）和5名跑步者（R）在自行车测力计上以最大耗氧量的60%运动30分钟。与NR相比，R组的HDL-C较高（49.2 +/- 2.6 vs 36.8 +/- 4.6 mg-dl-1; P < 0.05）。两组之间的血脂谱没有差异，运动也没有变化。与运动前R组相比，NR组的C-EF高于HDL（1.05 ± 0.17 vs 0.59 ± 0.09 mug/mg蛋白，P < 0.05）。急性运动增加了HDL作为R细胞胆固醇受体的能力，而在NR中降低。这些初步研究表明，HDL组分的功能变化可能在NR和R中不同，并且似乎受到急性运动的影响。
Physical activity has been shown to be inversely related to coronary heart disease (CHD). The role of high density lipoprotein (HDL) particles in the process of reverse cholesterol transport may be a fink between exercise and the prevention of CHD. The aim of the present study was to evaluate the effects of acute exercise on cholesterol efflux (C-EF) from human monocyte derived macrophages overloaded with cholesterol and subsequently incubated with HDL fractions isolated from plasma. Ten males; five sedentary (NR) and five runners (R) exercised 30 min on a cycle ergometer at 60% of maximum oxygen consumption. HDL-C was higher in R when compared with NR (49.2 +/- 2.6 vs 36.8 +/- 4.6 mg-dl-1; P < 0.05). Plasma lipid profiles did not differ between groups and were unchanged with exercise. C-EF was higher to HDL obtained from NR compared with R before exercise (1.05 +/- 0.17 vs 0.59 +/- 0.09 mug/mg protein, P < 0.05). Acute exercise increased HDL's ability to act as an acceptor of cellular cholesterol in R, whereas it decreased in NR. These preliminary studies suggest that functional changes in HDL fractions may differ in NR and R, and appear to be influenced by acute exercise.