N-cadherin/catenin complex as a master regulator of intercalated disc function.
N-cadherin/catenin complex as a master regulator of intercalated disc function.
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DOI：
10.3109/15419061.2014.908853
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发表时间：
2014-06
影响因子：
--
通讯作者：
Radice GL
中科院分区：
文献类型：
--
作者：
Vite A;Radice GL
细胞间粘附连接对于维持组织的物理完整性是必不可少的;这对于处于恒定机械负荷下的心脏尤其如此。心脏的正确功能取决于其组成心肌细胞的电和机械协调。位于杆状成年心肌细胞末端的闰盘（intercalateddisc，ID）结构含有多种负责结构信息整合和细胞间通讯的连接蛋白。根据经典的描述，ID由三种不同的连接复合物组成：粘附连接（AJ）、桥粒（Des）和间隙连接（GJ），它们共同作用以介导心肌细胞的机械和电耦合。然而，最近的形态学和分子研究表明，AJ和Des组分能够混合在一起，导致“混合粘附连接”或“区域组合物”。本文综述了近年来AJ组分在心脏稳态和疾病中的体内功能研究进展。
Intercellular adhesive junctions are essential for maintaining the physical integrity of tissues; this is particularly true for the heart that is under constant mechanical load. The correct functionality of the heart is dependent on the electrical and mechanical coordination of its constituent cardiomyocytes. The intercalated disc (ID) structure located at the termini of the rod shaped adult cardiomyocyte contains various junctional proteins responsible for the integration of structural information and cell-cell communication. According to the classical description, the ID consists of three distinct junctional complexes: adherens junction (AJ), desmosome (Des), and gap junction (GJ) that work together to mediate mechanical and electrical coupling of cardiomyocytes. However, recent morphological and molecular studies indicate that AJ and Des components are capable of mixing together resulting in a ‘hybrid adhering junction’ or ‘area composita’. This review summarizes recent progress in understanding the in vivo function(s) of AJ components in cardiac homeostasis and disease.
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影响因子：
37.8
作者：
Glukhov AV;Fedorov VV;Kalish PW;Ravikumar VK;Lou Q;Janks D;Schuessler RB;Moazami N;Efimov IR
通讯作者：
Efimov IR
影响因子：
20.1
作者：
Angst, BD;Khan, LUR;Gourdie, RG
通讯作者：
Gourdie, RG
影响因子：
2.7
作者：
Hirschy, A;Schatzmann, F;Perriard, JC
通讯作者：
Perriard, JC
影响因子：
14.9
作者：
Franceschini A;Szklarczyk D;Frankild S;Kuhn M;Simonovic M;Roth A;Lin J;Minguez P;Bork P;von Mering C;Jensen LJ
通讯作者：
Jensen LJ
影响因子：
9.5
作者：
Hirschy, Alain;Croquelois, Adrien;Ehler, Elisabeth
通讯作者：
Ehler, Elisabeth