Temporal coupling between subicular and hippocampal neurons underlies retention of trial-specific events
Temporal coupling between subicular and hippocampal neurons underlies retention of trial-specific events
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DOI：
10.1016/j.bbr.2006.05.038
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发表时间：
2006-11-11
影响因子：
2.7
通讯作者：
Hampson, Robert E.
中科院分区：
文献类型：
--
作者：
Deadwyler, Sam A.;Hampson, Robert E.
海马下托接收来自海马CA1区的大部分传出神经信息。因此，它占据了整合，转移和解决海马体与记忆和表现有关的活动的战略地位。我们以前已经证明，每个结构具有互补的合奏射击模式，一起允许信息被连续表示在一个延迟的非匹配样本（DNMS）任务的审判的时间过程。在这里，我们扩展这种分析，以显示精确的方式，在这两种结构中的特定神经元耦合时间上的延迟间隔上的一个单一的审判。这两种结构中的神经元编码与样品杠杆按压相关的位置特异性信息，但只有下托神经元在随后的可变延迟间期的早期部分继续发射。然而，交叉相关分析的多个尖峰列车表明，随着延迟的持续时间增加，其他下托神经元的时间耦合到下托神经元，在延迟的初始部分发射。后一个群体的下托神经元显示出与其他最初激活的下托神经元强烈的交叉相关放电，直到延迟的中途（< 15 s），但在更长的延迟间隔上与特定类型的海马神经元偶联，其放电对于正确的表现至关重要。因此，当试验延迟超过最小持续时间时，下托神经元在使海马“恢复在线”方面起着关键作用，从而允许两个结构在更长的时间间隔内合作桥接相关信息。(c)2006 Elsevier B.V.保留所有权利。
The subiculum receives the majority of efferent outflow of neural information from the CA1 region of the hippocampus. As such it occupies a strategic position in which to integrate, transfer and resolve activity from the hippocampus relating to memory and performance. We have previously demonstrated that each structure has complementary ensemble firing patterns that together allow information to be represented continuously over the time course of a trial in a delayed-non-match-to-sample (DNMS) task. Here, we extend this analysis to show the precise manner in which specific neurons in both structures are coupled temporally across the delay interval on a single trial. Neurons in both structures encode position-specific information related to the sample lever press, but only subicular neurons continue to fire during the early portion of the subsequent variable delay interval. However, cross-correlation analysis of multiple spike trains showed that as the delay increased in duration other subicular neurons were temporally coupled to the subicular neurons that fired in the initial part of the delay. This latter population of subicular neurons showed strong cross-correlated firing with other initially activated subicular neurons until midway through the delay (< 15 s), but on longer delay intervals were coupled to a specific type of hippocampal neuron whose firing was critical for correct performance. Subicular neurons, therefore, play a critical role in bringing the hippocampus "back online" when trial delays exceed the minimum duration thus allowing both structures to cooperatively bridge relevant information across longer time intervals than would not otherwise be possible. (c) 2006 Elsevier B.V. All rights reserved.