Graves' ophthalmopathy.
Graves' ophthalmopathy.
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DOI：
10.1056/nejmra0905750
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发表时间：
2010-02-25
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影响因子：
--
通讯作者：
Bahn RS
中科院分区：
文献类型：
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作者：
Bahn RS
格雷夫斯眼病，也称为格雷夫斯眼眶病，是一种潜在的视力威胁眼病，困扰了医生和科学家近两个世纪。一般发生在甲状腺功能亢进或有甲亢病史的Graves病患者中，Graves眼病也被称为甲状腺相关眼病或甲状腺眼病，因为它有时发生在甲状腺功能正常或甲状腺功能减退的慢性自身免疫性甲状腺炎患者中。这种疾病的年调整发病率为每10万人口中有16名女性和3名男性。这篇综述探讨了Graves眼病、甲状腺功能亢进和甲状腺皮肤病之间令人困惑的关系。我检查了临床特征，组织学发现和实验室研究，重点是在这种衰弱性疾病的新治疗方法的发展中可能有针对性的机制。
Graves’ ophthalmopathy, also called Graves’ orbitopathy, is a potentially sight-threatening ocular disease that has puzzled physicians and scientists for nearly two centuries. Generally occurring in patients with hyperthyroidism or a history of hyperthyroidism due to Graves’ disease, Graves’ ophthalmopathy is also known as thyroid-associated ophthalmopathy or thyroid eye disease, because it sometimes occurs in patients with euthyroid or hypothyroid chronic autoimmune thyroiditis. The condition has an annual adjusted incidence rate of 16 women and 3 men per 100,000 population. This review explores the perplexing relationship between Graves’ ophthalmopathy, hyperthyroidism, and thyroid dermopathy, the associated skin condition. I examine clinical features, histologic findings, and laboratory studies, with an emphasis on mechanisms that could be targeted in the development of new treatments for this debilitating disease.