The mechanism of expansion and the volatility it created in three pheromone gene clusters in the mouse (Mus musculus) genome.
The mechanism of expansion and the volatility it created in three pheromone gene clusters in the mouse (Mus musculus) genome.
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DOI：
10.1093/gbe/evp049
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发表时间：
2009-11-20
影响因子：
3.3
通讯作者：
Laukaitis CM
中科院分区：
文献类型：
--
作者：
Karn RC;Laukaitis CM
在家鼠中已经描述了三个蛋白质性信息素家族：雄激素结合蛋白（ABP）、外分泌腺分泌肽（ESP）和主要尿蛋白（MUP），其中每一个被认为传达不同的信息。这三种基因都是由小鼠基因组不同区域的大型基因簇编码的，这些基因簇在小鼠进化史上急剧扩张。我们报告的拷贝数变化之间的最近重复的Abp基因，这表明在这个基因区域的大幅波动。似乎这些基因组表现为低拷贝重复序列（LCR），通过非等位基因同源重组复制为相对较大的基因块。对基因转换的分析表明，它并没有导致以这种方式复制的旁系同源物之间的差异很低或不存在。我们评估了ESP和MUP基因区域的LCR模式的迹象，但没有发现任何显著大小的基因块重复的令人信服的证据。用Mouse Paralogy Browser对整个Abp基因区域的评估支持了在那里发生了实质性波动的结论。当将菌株与小家鼠或栗小家鼠Abp区域的全部或部分进行比较时，这一点尤其明显。在其他两个基因家族中没有观察到特别显着的波动性，我们讨论了这一点的意义，提出了三个家庭的小鼠蛋白质信息素的各种作用。
Three families of proteinaceous pheromones have been described in the house mouse: androgen-binding proteins (ABPs), exocrine gland–secreting peptides (ESPs), and major urinary proteins (MUPs), each of which is thought to communicate different information. All three are encoded by large gene clusters in different regions of the mouse genome, clusters that have expanded dramatically during mouse evolutionary history. We report copy number variation among the most recently duplicated Abp genes, which suggests substantial volatility in this gene region. It appears that groups of these genes behave as low copy repeats (LCRs), duplicating as relatively large blocks of genes by nonallelic homologous recombination. An analysis of gene conversion suggested that it did not contribute to the very low or absent divergence among the paralogs duplicated in this way. We evaluated the ESP and MUP gene regions for signs of the LCR pattern but could find no compelling evidence for duplication of gene blocks of any significant size. Assessment of the entire Abp gene region with the Mouse Paralogy Browser supported the conclusion that substantial volatility has occurred there. This was especially evident when comparing strains with all or part of the Mus musculus musculus or Mus musculus castaneus Abp region. No particularly remarkable volatility was observed in the other two gene families, and we discuss the significance of this in light of the various roles proposed for the three families of mouse proteinaceous pheromones.
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影响因子：
3.7
作者：
Logan DW;Marton TF;Stowers L
通讯作者：
Stowers L
影响因子：
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Cutler, Gene;Marshall, Lisa A.;Kassner, Paul D.
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Stowers, Lisa
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Netter, P
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