'Real-life experience': recurrence rate at 3 years with Hexvix(®) photodynamic diagnosis-assisted TURBT compared with good quality white light TURBT in new NMIBC-a prospective controlled study.
'Real-life experience': recurrence rate at 3 years with Hexvix(®) photodynamic diagnosis-assisted TURBT compared with good quality white light TURBT in new NMIBC-a prospective controlled study.
复制标题
DOI：
10.1007/s00345-017-2077-6
复制
发表时间：
2017-12
影响因子：
3.4
通讯作者：
Mariappan P
中科院分区：
文献类型：
--
作者：
Gallagher KM;Gray K;Anderson CH;Lee H;Stewart S;Donat R;Mariappan P
比较优质(GQ)PDD-TURBT和GQWL-TURBT治疗非肌肉浸润性膀胱癌(NMIBC)的3年复发率(RR-3y)。所有新的、连续的、在大学医院服务中首先通过TURBT标准获得“高质量”标准的NMIBC都被前瞻性地招募到这项为期4年的研究中。前瞻性收集2007/8年度所有WL-TURBT的数据，并与2009/10年度的PDD-TURBT进行比较。每个队列中只包括符合严格“良好质量标准”的切除，以控制切除质量，然后根据人口统计学和病理标准进一步1：1匹配病例。主要结果是3年的总体复发率和特定风险组的复发率。在招募的808名患者中，345名NMIBC患者接受了GQ-TURBT，并纳入其中。在1：1配对的基础上，RR-3y在GQ-PDD总体上显著减少[RR-3y：GQ-PDD：57/146(39.0%)，GQ-WL：72/135(53.3%)OR=0.56(0.35-0.90)p<0.001]，1：1配对基础上[RR GQ-PDD：29/118(24.6)vs 59/118(50.0)or 0.33(0.19-0.57)p<；(0.001)]。益处在高危患者中最为显著：接受GQ-PDD治疗的高危患者的RR-3Y为25/48(52.1%)，而GQ-WL为28/35(80%)[OR0.27(0.10-0.74)p=0.0.01]。当在常规实践中对所有新的膀胱肿瘤切除采用PDD时，在我们的现实生活中，PDD似乎与3年后显著降低复发率有关，特别是在高危患者中。本文的在线版本(doi：10.1007/s0034520172077-6)包含补充材料，授权用户可以使用。
To compare the recurrence rate at 3 years (RR-3y) for non-muscle invasive bladder cancer (NMIBC) between good quality (GQ) PDD-TURBT and GQWL-TURBT where PDD is used in routine practice for all new tumours. All new, consecutive, NMIBC that received “good quality” criteria first TURBT across a university hospital service were prospectively recruited to this study over a 4-year period. Data were prospectively collected on all WL-TURBTs performed in 2007/8 and compared with PDD-TURBT from 2009/10. Only resection meeting strict “good quality criteria” were included from each cohort to control for resection quality, then cases were further matched 1:1 based on demographic and pathological criteria. The primary outcome was overall and risk group-specific recurrence rate at 3 years. Of 808 patients recruited, 345 had GQ-TURBT for NMIBC and were included. RR-3y was significantly less for GQ-PDD overall [RR-3y: GQ-PDD: 57/146 (39.0%), GQ-WL: 72/135 (53.3%) OR = 0.56 (0.35–0.90) p = 0.02] and on a 1:1 matched pair basis [RR GQ-PDD: 29/118 (24.6) vs. 59/118 (50.0) OR 0.33 (0.19–0.57) p < 0.001)]. Benefit was most marked in high-risk patients: RR-3y in high-risk patients treated with GQ-PDD was 25/48 (52.1%) vs. 28/35 (80%) for GQ-WL [OR 0.27 (0.10–0.74) p = 0.01]. When adopted for all new bladder tumour resections in routine practice, PDD appears to be associated with significantly reduced recurrence rates at 3 years in our “real life” experience, particularly in high-risk patients. The online version of this article (doi:10.1007/s00345-017-2077-6) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
2.6
作者：
Mayr, Roman;Burger, Maximilian
通讯作者：
Burger, Maximilian
影响因子：
2.5
作者：
Kennedy-Martin T;Curtis S;Faries D;Robinson S;Johnston J
通讯作者：
Johnston J
影响因子：
23.4
作者：
Mariappan, Paramananthan;Zachou, Alexandra;Grigor, Kenneth M.
通讯作者：
Grigor, Kenneth M.
影响因子：
23.4
作者：
Sylvester, Richard J.;Oosterlinck, Willem;Babjuk, Marek
通讯作者：
Babjuk, Marek
影响因子：
23.4
作者：
Burger, Maximilian;Grossman, H. Barton;Jocham, Dieter
通讯作者：
Jocham, Dieter