Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules
Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules
复制标题
通过水分子的核磁共振弛豫对纳米悬浮液的团聚过程进行无损研究
DOI：
10.1016/j.ejps.2021.105908
复制
发表时间：
2021
影响因子：
4.6
通讯作者：
Yoshinori Onuki
中科院分区：
文献类型：
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作者：
Kotaro Okada;Yoshihiro Hayashi;Shungo Kumada;Yoshinori Onuki
本研究利用核磁共振 (NMR) 弛豫研究了悬浮液中纳米颗粒的团聚情况。使用吲哚美辛和聚乙烯吡咯烷酮分别作为活性药物成分（API）和稳定剂，通过湿法珠磨制备纳米混悬剂。使用基于多光散射技术的色散分析仪的传输曲线证实，湿式珠磨后立即在 25 °C 下发生团聚。在这项研究中，我们关注的是水分子，而不是纳米颗粒，并使用时域核磁共振（TD-NMR）技术获得了水分子的T2弛豫时间（T2）。贮藏期间，T2值在贮藏初期迅速上升。在悬浮体系中，由于已知水分子的 T2 值反映了颗粒的表面积，因此观察到的 T2 值快速增加表明纳米颗粒发生团聚。因此，表明纳米悬浮液T2弛豫的测量可以评估团聚过程。该技术直接观察水分子而不是纳米颗粒。因此，我们相信 TD-NMR 是一种通用技术，与 API 或聚合物的类型无关。
This study investigated an agglomeration of nanoparticles in a suspension using nuclear magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead milling using indomethacin and polyvinylpyrrolidone as an active pharmaceutical ingredient (API) and stabilizer, respectively. Transmission profiles using a dispersion analyzer based on multilight scattering technology confirmed that agglomeration occurred at 25 °C immediately after wet bead milling. In this study, we focused on the water molecules, not nanoparticles, and obtained theT2relaxation time (T2) of the water molecules using the time-domain NMR (TD-NMR) technique. During the storage period, theT2value rapidly increased at the beginning of the storage. In a suspension system, because theT2value of water molecules is known to reflect the surface area of the particle, the observed rapid increase inT2value indicated an agglomeration of nanoparticles. Therefore, it was shown that the measurement ofT2relaxation of a nanosuspension could evaluate the agglomeration process. This technique directly observes water molecules as opposed to nanoparticles. Thus, we believe that TD-NMR is a general-purpose technique that is independent of the type of API or polymer.