Tissue Adhesives as Active Implants
Tissue Adhesives as Active Implants
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DOI：
10.1007/8415_2010_48
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Kohane, Daniel S.
中科院分区：
文献类型：
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作者：
Mizrahi, Boaz;Weldon, Christopher;Kohane, Daniel S.
Tissue adhesives are substances that hold tissues together, and could be broadly applicable in medicine and surgery. In appropriate circumstances, such materials could be attractive alternatives to sutures and staples since they can be applied more quickly, causes less pain and may require less equipment. In addition, there is no risk to the practitioner from sharp instruments (Singer et al., Acad. Emerg. Med. 5(2):94, 1998), and they may obviate the need for suture removal (Coulthard et al., Cochrane Database Syst. Rev. 5:CD004287, 2010). An ideal surgical tissue adhesive should allow rapid adhesion and maintain strong and close apposition of wound edges for an amount of time sufficient to allow wound healing. It should not interfere with body's natural healing mechanisms and should degrade without producing an excessive localized or generalized inflammatory response (Mobley et al., Facial Plast. Surg. Clin. North Am. 10(2):147, 2002). The clinical and scientific potential of adhesives can be enhanced by a variety of functionalities that may not be directly related to their function as glues or sealants. Here we will review adhesives in general, with an emphasis on enhancements that render those otherwise passive materials "active". We note that some glues also have intrinsic secondary functionalities that can be direct or indirect consequences of their primary function, but that is not the focus of this chapter. (For example, they may augment local hemostasis directly, or by improving tissue apposition, without affecting clotting mechanisms (Reece et al., Am. J. Surg. 182(2 Suppl):40S, 2001)).
