Participants' perceptions of motivation, randomisation and withdrawal in a randomised controlled trial of interventions for prevention of depression
Participants' perceptions of motivation, randomisation and withdrawal in a randomised controlled trial of interventions for prevention of depression
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DOI：
10.1136/jme.2008.028035
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发表时间：
2009-12-01
影响因子：
4.1
通讯作者：
Walker, J.
中科院分区：
文献类型：
--
作者：
Busby-Grant, J.;Mackinnon, A. J.;Walker, J.
目的和背景：关于参与者如何看待预防试验，特别是旨在预防精神疾病的试验，目前知之甚少。这项研究考察了参与者参与试验的动机以及他们对随机化的看法和退出一项预防抑郁的随机对照试验(RCT)的能力。方法：参与者是居住在澳大利亚城市和地区的老年人(N=900)，他们报告抑郁症状升高，并同意参加预防抑郁的RCT。结果：大多数受试者对参与试验的利他动机、相对缺乏对随机化的关注和对试验的承诺三者表现出一致的态度。研究结果表明，参加精神疾病预防试验的受试者可能对研究试验持积极态度(例如，高承诺、低个人收益期望)。关键人因素与试验相关态度之间关系的确定使得能够对参与者群体进行概况分析，这可以为未来预防试验中参与者和研究项目的招募战略和互动提供信息。
Aims and background: Little is known about how participants perceive prevention trials, particularly trials designed to prevent mental illness. This study examined participants' motives for participating in a trial and their views of randomisation and the ability to withdraw from a randomised controlled trial (RCT) for prevention of depression.Methods: Participants were older adults reporting elevated depression symptoms (N = 900) living in urban and regional locations in Australia who had consented to participate in an RCT of interventions to prevent depression. Participants rated their agreement with various statements describing motivations for enrolment in the trial and opinions regarding randomisation and withdrawal.Results: The majority of participants expressed a triad of altruistic motivation for participation, relative lack of concern about randomisation and commitment to the trial. Certain subgroups of participants, such as women and those with higher depression scores, reported higher levels of concern about specific issues.Conclusions: The findings suggest that participants enrolled in prevention trials for mental illness are likely to hold positive attitudes (eg, high commitment, low expectation of personal gain) towards research trials. The identification of relationships between key person factors and trial-related attitudes enabled profiling of participant groups, which can inform recruitment strategies and interactions of participants and research projects in future prevention trials.