Analysis of 13 fentanils, including sufentanil and carfentanil, in human urine by liquid chromatography-atmospheric-pressure ionization-tandem mass spectrometry.
Analysis of 13 fentanils, including sufentanil and carfentanil, in human urine by liquid chromatography-atmospheric-pressure ionization-tandem mass spectrometry.
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采用液相色谱-大气压电离-串联质谱法分析人尿液中的 13 种芬太尼，包括舒芬太尼和卡芬太尼。
DOI：
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发表时间：
2006
影响因子：
2.5
通讯作者：
J. Bernert
中科院分区：
文献类型：
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作者：
Lanqing Wang;J. Bernert
本文介绍了一种灵敏的半自动分析人体尿液中芬太尼及其代谢物的方法。该方法采用固相萃取尿样，然后用液相色谱-大气压电离-串联质谱仪。在这项研究中，13种分析物中的6种纳入了同位素标记的内标。估计检出限为3至27pg/mL，大多数情况下都观察到了良好的准确度和长期精密度。这种方法对于快速和灵敏地筛选人体尿样中的一些芬太尼及其代谢物作为暴露指标应该是有用的。
A sensitive, semiautomated method for the analysis of several fentanils and fentanil metabolites in human urine is described. This method uses solid-phase extraction of urine samples followed by liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry. Isotopically labeled internal standards were included for 6 of the 13 analytes in this study. Estimated detection limits ranged from 3 to 27 pg/mL, and good accuracy and long-term precision were observed in most cases. This method should be useful for the rapid and sensitive screening of human urine samples for a number of fentanils and their metabolites as indicators of exposure.