Serological and clinical comparison of children and adults with anti-endomysial antibodies
Serological and clinical comparison of children and adults with anti-endomysial antibodies
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DOI：
10.1007/s10875-006-9062-y
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发表时间：
2007-03-01
影响因子：
9.1
通讯作者：
Nikolic, Milos M.
中科院分区：
文献类型：
--
作者：
Bonaci-Nikolic, Branka;Andrejevic, Sladjana;Nikolic, Milos M.
对38例成人（男5例，女33例）和37例儿童（男15例，女22例）进行抗肌内膜抗体（AEA）、抗核抗体（ANA）、抗壁抗体（阿帕）、抗甲状腺微粒体抗体（ATMA）、抗甲状腺球蛋白抗体（ATGA）、抗平滑肌抗体（SMA）和抗线粒体抗体（AMA）的检测。抗组织转氨酶（tTG）、抗可提取核抗原（ENA）和抗肌动蛋白（AAA）抗体检测结果表明，ANA、阿帕、ATGA、SMA、AMA和AAA在儿童和成人中的频率无显著性差异。ATMA（p < 0.001）和抗ENA（p < 0.05）阳性在成人中更常见。抗Ro/SSA阳性率为7/38例成人和1/37例儿童（p < 0.05）。成人更常发生与自身免疫性疾病相关的无症状形式的乳糜泻（p < 0.001）。我们首次证明，尽管成人和儿童的ANA阳性率没有差异，但成人的ANA更常靶向ENA，尤其是Ro/SSA抗原。这种ANA特异性的原因可能是成年人接触麸质的时间较长。
We compared serological and clinical presentation of 38 adults (5 males, 33 females) and 37 children (15 boys, 22 girls) with anti-endomysial antibodies (AEA).AEA, antinuclear (ANA), anti-parietal (APA), anti-thyroid microsomal (ATMA), anti-thyreoglobulin (ATGA), anti-smooth muscle (SMA) and anti-mitochondrial (AMA) antibodies were detected by IIF. Anti-tissue transglutaminase (tTG), anti-extractable nuclear antigens (ENA) and anti-actin (AAA) antibodies were studied by ELISA.There were no differences in frequency of ANA, APA, ATGA, SMA, AMA and AAA in children and adults. ATMA (p < 0.001) and anti-ENA (p < 0.05) positivity were more frequently found in adults. Anti-Ro/SSA had 7/38 adults and 1/37 children (p < 0.05). Adults had more frequently silent form of celiac disease associated with autoimmune diseases (p < 0.001).We are the first to demonstrate that in spite of no difference in ANA positivity in adults and children, ANA in adults more frequently target ENA, especially Ro/SSA antigen. The reason for this ANA specificity could be the longer gluten exposure in adults.