ANTIVIRAL ACTIVITY OF THE PREGNANCY RECOGNITION HORMONE OVINE TROPHOBLAST PROTEIN-1
ANTIVIRAL ACTIVITY OF THE PREGNANCY RECOGNITION HORMONE OVINE TROPHOBLAST PROTEIN-1
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DOI：
10.1016/s0006-291x(88)80109-8
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发表时间：
1988-04-29
影响因子：
3.1
通讯作者：
JOHNSON, HM
中科院分区：
文献类型：
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作者：
PONTZER, CH;TORRES, BA;JOHNSON, HM
绵羊滋养层蛋白-1（oTP-1）是一种抗黄体溶解蛋白，在母体识别妊娠中起重要作用。它与来自不同物种的α干扰素（IFN-α s）具有45-70%的氨基酸序列同源性。我们在此表明，纯化的oTP-1具有高的特异性抗病毒活性（2-3 × 10 - 6）。108单位/mg蛋白质），因此与任何已知的IFN一样有效。oTP-1在抗原性上是不同的，但确实显示出与绵羊和牛IFN-α s的抗原关系oTP-1在妊娠第12- 16天的孕体培养液和妊娠第60天的尿囊液中可显示抗病毒活性。我们的功能性和抗原性表征表明oTP-1是一种IFN-α。其执行与IFN-α相关的经典作用，也是负责母体识别妊娠的主要孕体分泌产物。
Ovine trophoblast protein-1 (oTP-1) is an antiluteolytic protein which plays an important role in maternal recognition of pregnancy. It exhibits a 45-70% amino acid sequence homology with alpha interferons (IFN-.alpha.s) from various species. We show here that purified oTP-1 has high specific antiviral activity (2-3 .times. 108 units/mg protein) and is thus as potent as any known IFN. oTP-1 is antigenically distinct but does show antigenic relation to both ovine and bovine IFN-.alpha.s. The antiviral activity of oTP-1 could be demonstrated in Day 12-Day 16 conceptus culture medium and in allantoic fluid from Day 60 of pregnancy. Our functional and antigenic characterization suggests that oTP-1 is a type of IFN-.alpha. which performs classic roles associated with IFN-.alpha., as well as being the primary conceptus secretory product responsible for maternal recognition of pregnancy.