Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection
Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection
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DOI：
10.1101/lm.2135211
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发表时间：
2011-08-01
影响因子：
2
通讯作者：
Wagner, Anthony D.
中科院分区：
文献类型：
--
作者：
Chen, Janice;Olsen, Rosanna K.;Wagner, Anthony D.
海马亚区CA(3)和CA(1)被假设分别对联想预测的产生和联想不匹配的检测有不同的支持作用。利用高分辨率功能磁共振成像，我们在联想提取过程中以及在随后将记忆与匹配或不匹配的决策探针进行比较时，检测了海马亚区的激活情况。齿状回/CA(2/3)、CA(1)和其他内侧颞叶子区域的活动追踪联想提取的成功与否，而CA(1)和鼻周皮质的活动追踪联想不匹配的情况。这些数据支持了CA(1)作为一个“比较器”的假设，即当过去的记忆和当前的感觉输入不一致时能够检测到。
Hippocampal subfields CA(3) and CA(1) are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes. Activity in the dentate gyrus/CA(2/3), CA(1), and other medial temporal lobe subregions tracked associative retrieval success, whereas activity in CA(1) and the perirhinal cortex tracked the presence of associative mismatches. These data support the hypothesis that CA(1) acts as a "comparator," detecting when memory for the past and sensory input in the present diverge.