Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.
Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.
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DOI：
10.3390/ijms17010128
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发表时间：
2016-01-19
影响因子：
5.6
通讯作者：
Forsyth NR
中科院分区：
文献类型：
--
作者：
Akram KM;Patel N;Spiteri MA;Forsyth NR
未受干扰的成人肺的组织更新是非常缓慢的。然而，在损伤或损伤后，一组专门的兼性肺祖细胞被激活，通过称为再生的修复过程来补充受损组织。这一过程的中断导致纤维化愈合，导致异常肺重塑和器官功能障碍。损伤后再生失败导致各种不可治愈的肺部疾病，包括慢性阻塞性肺病（COPD）和特发性肺纤维化。因此，鉴定真正的内源性肺祖细胞/干细胞及其再生途径对于下一代治疗开发至关重要。最近的研究提供了令人兴奋的和新的见解出生后肺发育和损伤后肺再生的原生肺祖细胞。此外，骨髓干细胞、胚胎干细胞和诱导性多能干细胞（iPSC）的外源性应用显示出它们在修复受损和患病肺中的再生能力的证据。随着现代组织工程技术的出现，使用去细胞化组织支架和干细胞在实验室中进行全肺再生现在正在成为现实。在这篇综述中，我们将重点介绍我们在肺再生和干细胞介导的治疗策略在打击不可治愈的肺部疾病的发展的认识。
The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC) show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases.