Clinical Presentation and Birth Outcomes Associated with Respiratory Syncytial Virus Infection in Pregnancy
Clinical Presentation and Birth Outcomes Associated with Respiratory Syncytial Virus Infection in Pregnancy
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DOI：
10.1371/journal.pone.0152015
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发表时间：
2016-03-31
期刊：
影响因子：
3.7
通讯作者：
Englund, Janet A.
中科院分区：
文献类型：
--
作者：
Chu, Helen Y.;Katz, Joanne;Englund, Janet A.
研究背景呼吸道合胞病毒（Respiratory syncytial virus，RSV）是世界范围内引起儿童病毒性肺炎的最主要病原。母体疫苗可以保护母亲和婴儿免受RSV疾病的侵害。RSV在孕妇和产后妇女的流行病学和临床表现是没有很好的描述。MethodsData收集的前瞻性，随机试验的流感疫苗接种在尼泊尔南部农村的孕妇。妇女在怀孕的第二个三个月登记，并随访至产后六个月。对发热性呼吸道疾病进行每周一次的家庭监测。中鼻拭子收集的呼吸道疾病发作进行了测试RSV实时polymerase chain reaction.ResultsRSV检测14（0.4%）疾病发作在3693名妇女超过3554人年的监测从2011年至2014年。RSV发病率总体为3.9/1000人年，9月至12月为11.8/1000人年。7名（50%）妇女因RSV疾病寻求护理;无死亡。在7例（50%）妊娠期疾病中，所有患者均活产，其中2例（29%）早产，中位出生体重为3060克。相比之下，469例（13%）早产，妊娠期间无RSV的女性中位出生体重为2790克。7产后RSV感染的母亲，RSV检测到4（57%），他们的infants.ConclusionsRSV是一个不常见的原因，在尼泊尔怀孕期间的母亲发热性呼吸道疾病。这些数据将为资源有限环境中的RSV预防和治疗策略提供信息。
BackgroundRespiratory syncytial virus (RSV) is the most important cause of viral pneumonia in children worldwide. A maternal vaccine may protect both the mother and infant from RSV illness. The epidemiology and clinical presentation of RSV in pregnant and postpartum women is not well-described.MethodsData were collected from a prospective, randomized trial of influenza immunization in pregnant women in rural southern Nepal. Women were enrolled in their second trimester of pregnancy and followed until six months postpartum. Active weekly home-based surveillance for febrile respiratory illness was performed. Mid-nasal swabs collected with episodes of respiratory illness were tested for RSV by real-time polymerase chain reaction.ResultsRSV was detected in 14 (0.4%) illness episodes in 3693 women over 3554 person-years of surveillance from 2011-2014. RSV incidence was 3.9/1000 person-years overall, and 11.8/1000 person-years between September and December. Seven (50%) women sought care for RSV illness; none died. Of the 7 (50%) illness episodes during pregnancy, all had live births with 2 (29%) preterm births and a median birthweight of 3060 grams. This compares to 469 (13%) preterm births and a median birthweight of 2790 grams in women without RSV during pregnancy. Of the 7 mothers with postpartum RSV infection, RSV was detected in 4 (57%) of their infants.ConclusionsRSV was an uncommon cause of febrile respiratory illness in mothers during pregnancy in Nepal. These data will inform prevention and therapeutic strategies against RSV in resource-limited settings.