Macrophage Chitinase 1 Stratifies Chronic Obstructive Lung Disease
Macrophage Chitinase 1 Stratifies Chronic Obstructive Lung Disease
复制标题
DOI：
10.1165/2009-0122rc
复制
发表时间：
2009-10-01
影响因子：
6.4
通讯作者：
Holtzman, Michael J.
中科院分区：
文献类型：
--
作者：
Agapov, Eugene;Battaile, John T.;Holtzman, Michael J.
慢性炎症性肺病的诊断和治疗受到对可深入了解发病机制的个体化生物标志物的需求的限制。在此，我们表明，慢性阻塞性肺病的小鼠模型表现出肺几丁质酶产量的增加，但无法预测哪些几丁质酶家族成员在患有相应肺病的人类中可能会相应增加。此外，我们证明，在患有严重慢性阻塞性肺疾病的受试者亚群中，肺巨噬细胞产生的几丁质酶 1 选择性增加，并且这种增加反映在血浆水平上。这些发现提供了一种非侵入性追踪慢性肺病中替代激活的巨噬细胞的方法，从而更好地区分异质患者群体中的分子表型。
Diagnosis and therapy of chronic inflammatory lung disease is limited by the need for individualized biomarkers that provide insight into pathogenesis. Herein we show that mouse models of chronic obstructive lung disease exhibit an increase in lung chitinase production but cannot predict which chitinase family member may be equivalently increased in humans with corresponding lung disease. Moreover, we demonstrate that lung macrophage production of chitinase 1 is selectively increased in a subset of subjects with severe chronic obstructive pulmonary disease, and this increase is reflected in plasma levels. The findings provide a means to noninvasively track alternatively activated macrophages in chronic lung disease and thereby better differentiate molecular phenotypes in heterogeneous patient populations.