PERIPHERAL VASCULAR EFFECTS OF NORADRENALINE, ISOPROPYLNORADRENALINE AND DOPAMINE
PERIPHERAL VASCULAR EFFECTS OF NORADRENALINE, ISOPROPYLNORADRENALINE AND DOPAMINE
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DOI：
10.1093/oxfordjournals.bmb.a070031
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发表时间：
1963-01-01
影响因子：
6.7
通讯作者：
COBBOLD, AF
中科院分区：
文献类型：
--
作者：
ALLWOOD, MJ;GINSBURG, J;COBBOLD, AF
Barcroft和Konzett（1949年）首先研究了去甲肾上腺素对人体外周的影响;胺被证明是皮肤和骨骼肌血管的直接收缩剂，在静脉和动脉输注后导致前臂和小腿的血流量减少。这些对人体的研究与概念一致，然后获得认可并基于动物研究，即去甲肾上腺素是交感血管收缩神经末梢的递质（von Euler，1956）。Barcroft和Swan（1953）进一步讨论了去甲肾上腺素对人体外周循环的作用，图1总结了去甲肾上腺素、肾上腺素、异丙基去甲肾上腺素和多巴胺的血管作用的一般比较。但仅在嗜铬细胞瘤的情况下，去甲肾上腺素的分泌可能显著增加，才证明了这种关联（Pickering，1955）。然而，在500例原发性高血压患者中，去甲肾上腺素的排泄并未增加（von Euler，Hellner & Purkhold，1954）。
Peripheral effects of noradrenaline in man were first investigated by Barcroft & Konzett (1949); the amine was shown to be a direct constrictor of blood vessels in skin and skeletal muscle, causing a reduction of blood flow in the forearm and the calf after both intravenous and intra-arterial infusions. These studies in man accorded well with the concept, then gaining acceptance and based on studies in animals, that noradrenaline was the transmitter at sympathetic vasoconstrictor nerve-endings (von Euler, 1956). The effect of noradrenaline on the human peripheral circulation has been further discussed by Barcroft & Swan (1953), and a general comparison of the vascular actions of noradrenaline, adrenaline, isopropylnoradrenaline and dopamine is summarized in fig. 1.From time to time, attempts have been made to involve noradrenaline in the production or maintenance of hypertension in man, but an association has been demonstrated only in cases of phaeochromocytoma where the excretion of noradrenaline may be markedly increased (Pickering, 1955). The excretion of noradrenaline was not, however, raised in 500 patients with essential hypertension (von Euler, Hellner & Purkhold, 1954).