New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis.
New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis.
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DOI：
10.1016/j.ebiom.2022.104345
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发表时间：
2022-12
期刊：
影响因子：
11.1
通讯作者：
Song M
中科院分区：
文献类型：
--
作者：
Zeng H;Yuan C;Morze J;Fu R;Wang K;Wang L;Sun F;Ji JS;Giovannucci EL;Song M
有限的数据表明，结直肠癌（CRC）患者发生2型糖尿病（T2 D）的风险较高。我们在三个大的队列中前瞻性地检查了患有和不患有CRC的个体之间的T2 D风险，并进行了荟萃分析。我们评估了来自护士健康研究的111，485名女性，来自护士健康研究II的112，958名女性和来自卫生专业人员随访研究的46，581名男性的CRC和T2 D诊断。我们使用多变量考克斯回归和随时间变化的协变量来计算T2 D与CRC诊断相关的风险比（HR）。我们进一步对队列研究进行了系统回顾和荟萃分析。长达36年的随访（690万人年），我们记录了3402例CRC病例和26,469例T2 D病例。与非CRC个体相比，CRC患者更有可能发展为T2 D（多变量校正HR 1.20，95% CI 1.05-1.38）。这种关联在T2 D风险因素较少的个体中最为明显。在7项队列研究（1，061，744例受试者）的荟萃分析中，CRC与较高的T2 D风险相关（荟萃分析HR 1.21，95% CI 1.11-1.31，I2 = 57.9%）。根据CRC持续时间，在CRC诊断的前10年中观察到统计学显著相关性，但在10年后未观察到统计学显著相关性（≤5年，荟萃分析HR 1.32，95% CI 1.27-1.36; 5.1-10年，1.14 [1.04-1.25]; >10年，1.14 [0.91-1.37]）。CRC与T2 D风险增加相关，特别是在CRC诊断后的前十年。我们的研究结果强调了T2 D预防对CRC生存护理的重要性。NHS队列基础设施补助金（UM 1 CA 186107）、资助癌症研究的NHS计划项目补助金（P01 CA 87969）、NHS II队列基础设施补助金（U 01 CA 176726）、HPFS队列基础设施补助金（U 01 CA 167552）和中国医学科学院医学科学创新基金（2021-I2 M-1-010）。
Limited data indicate that patients with colorectal cancer (CRC) are at higher risk of developing type 2 diabetes (T2D). We prospectively examined the risk of T2D between individuals with and without CRC in three large cohorts and conducted a meta-analysis. We assessed the diagnosis of CRC and T2D among 111,485 women from the Nurses' Health Study, 112,958 women from the Nurses' Health Study II, and 46,581 men from the Health Professionals Follow-up Study. We used multivariable Cox regression with time-varying covariates to calculate the hazard ratio (HR) of T2D in relation to CRC diagnosis. We further performed a systematic review and meta-analysis of cohort studies. Up to 36 years of follow-up (6.9 million person-years), we documented 3402 incident CRC cases and 26,469 T2D cases. Compared to non-CRC individuals, those with CRC were more likely to develop T2D (multivariable-adjusted HR 1.20, 95% CI 1.05–1.38). The association was most evident for individuals with fewer risk factors for T2D. In the meta-analysis of seven cohort studies (1,061,744 participants), CRC was associated with higher T2D risk (meta-analysis HR 1.21, 95% CI 1.11–1.31, I2 = 57.9%). By CRC duration, a statistically significant association was observed in the first 10 years but not after 10 years of CRC diagnosis (≤5 years, meta-analysis HR 1.32, 95% CI 1.27–1.36; 5.1–10 years, 1.14 [1.04–1.25]; >10 years, 1.14 [0.91–1.37]). CRC was associated with increased T2D risk, especially in the first ten years after CRC diagnosis. Our findings highlight the importance of T2D prevention for CRC survivorship care. NHS cohort infrastructure grant (UM1 CA186107), NHS program project grant that funds cancer research (P01 CA87969), NHS II cohort infrastructure grant (U01 CA176726), HPFS cohort infrastructure grant (U01 CA167552) and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-010).
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DOI：
10.1093/intqhc/mzy124
发表时间：
2019-03-01
期刊：
International journal for quality in health care : journal of the International Society for Quality in Health Care
影响因子：
--
作者：
Griffiths RI;Keating NL;Bankhead CR
通讯作者：
Bankhead CR
影响因子：
5.4
作者：
ChasanTaber, S;Rimm, EB;Willett, WC
通讯作者：
Willett, WC
影响因子：
28.4
作者：
Hwangbo, Yul;Kang, Danbee;Cho, Juhee
通讯作者：
Cho, Juhee
糖尿病的医疗标准 - 2012年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
8.8
作者：
Khan, N. F.;Mant, D.;Carpenter, L.;Forman, D.;Rose, P. W.
通讯作者：
Rose, P. W.