Protective Effect of Monascus-Fermented Red Mold Rice against Alcoholic Liver Disease by Attenuating Oxidative Stress and Inflammatory Response
Protective Effect of Monascus-Fermented Red Mold Rice against Alcoholic Liver Disease by Attenuating Oxidative Stress and Inflammatory Response
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DOI：
10.1021/jf202577t
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发表时间：
2011-09-28
影响因子：
6.1
通讯作者：
Pan, Tzu-Ming
中科院分区：
文献类型：
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作者：
Cheng, Chin-fu;Pan, Tzu-Ming
据报道，红曲霉NTU 568发酵大米具有多种生物效应，包括抗肿瘤、抗高甘油三酯血症、抗氧化和抗炎活性。然而，其在酒精性肝病发病机制中的作用仍不清楚。本研究以慢性酒精诱导小鼠为实验模型，对红曲霉发酵红霉米（RMR）的肝保护作用进行体内评价。以307.5 mg/kg（1倍）、615 mg/kg（2倍）和1537.5 mg/kg（5倍）的RMR剂量口服酒精诱导小鼠5周，而对照组仅给药。RMR治疗显著降低了血清转氨酶（天冬氨酸转氨酶和丙氨酸转氨酶）、肝脏甘油三酯和总胆固醇积累水平的升高。此外，RMR提高肝脏抗氧化能力，减少肝细胞损伤（脂肪变性）和降低组织炎症细胞因子水平。这些发现表明，红曲霉发酵的RMR可能通过减轻氧化应激、炎症反应和脂肪变性，代表了一种对抗酒精性肝病的新型保护策略。
Monascus purpureus NTU 568 fermented rice is reported to exhibit a wide variety of biological effects, including antitumor, antihypertriglyceridemia, antioxidant, and anti-inflammatory activities. However, its role in the pathogenesis of alcoholic liver disease remains obscure. In this study, the hepatoprotective effects of Monascus-fermented red mold rice (RMR) was evaluated in vivo using chronic alcohol-induced mice as an experimental model. The alcohol-induced mice were orally treated with RMR at 307.5 mg/kg (1-fold), 615 mg/kg (2-fold), and 1537.5 mg/kg (5-fold) for 5 weeks, whereas controls received vehicle only. Treatment with RMR significantly attenuated the increased level of serum transaminases (aspartate aminotransferase and alanine aminotransferase) and hepatic triglyceride and total cholesterol accumulation. Furthermore, RMR elevates hepatic antioxidant ability that reduced hepatic cell damage (steatosis) and decreased tissue inflammatory cytokine levels. These findings suggest that Monascus-fermented RMR may represent a novel, protective strategy against alcoholic liver disease by attenuating oxidative stress, inflammatory response, and steatosis.