Are Worry and Rumination Specific Pathways Linking Neuroticism and Symptoms of Anxiety and Depression in Patients with Generalized Anxiety Disorder, Major Depressive Disorder and Mixed Anxiety-Depressive Disorder?
Are Worry and Rumination Specific Pathways Linking Neuroticism and Symptoms of Anxiety and Depression in Patients with Generalized Anxiety Disorder, Major Depressive Disorder and Mixed Anxiety-Depressive Disorder?
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DOI：
10.1371/journal.pone.0156169
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发表时间：
2016-05-31
期刊：
影响因子：
3.7
通讯作者：
Ferreiro, Fatima
中科院分区：
文献类型：
--
作者：
Merino, Hipolito;Senra, Carmen;Ferreiro, Fatima
本研究探讨了三组患者的神经质（高阶脆弱性因素）、忧虑、沉思和反思（二阶脆弱性因素）认知风格与焦虑和抑郁症状之间的关系：广泛性焦虑症（GAD）、重度抑郁症（MDD）和混合性焦虑抑郁症（MADD）患者。一百三十四名患者完成了一系列调查问卷，包括神经质、担忧、沉思（沉思和反思）、焦虑和抑郁的测量。多重中介分析表明，在三个诊断组中，忧虑可能是连接神经质和焦虑症状的中介机制，而沉思-沉思可能在 MDD 和 MADD 患者以及 GAD 患者的神经质和抑郁症状之间发挥中介作用。总体而言，我们的研究结果表明，神经质可能通过分别涉及担忧或沉思的特定联系增加焦虑和抑郁症状的风险，并且无论焦虑或抑郁是否是主要情绪，或者它们是否共存但没有任何明显的优势，担忧和沉思都可能在所检查的三组中起作用；因此，我们假设存在“特定跨诊断”机制。
This study examines the relationships between neuroticism (higher-order vulnerability factor), the cognitive styles of worry, brooding and reflection (second-order vulnerability factors) and symptoms of anxiety and depression in three groups of patients: patients with Generalized Anxiety Disorder (GAD), with Major Depressive Disorder (MDD) and with Mixed Anxiety-Depressive Disorder (MADD). One hundred and thirty four patients completed a battery of questionnaires including measures of neuroticism, worry, rumination (brooding and reflection), anxiety and depression. Multiple mediation analyses indicate that worry may act as a mediating mechanism linking neuroticism and anxiety symptoms in the three diagnostic groups, whereas brooding-rumination may play a mediating role between neuroticism and depressive symptoms in patients with MDD and MADD and, with less certainty, in patients with GAD. Overall, our findings suggest that neuroticism may increase the risk of anxious and depressive symptoms via specific links involving either worry or brooding, respectively, and that both worry and brooding may operate in the three groups examined, irrespectively of whether anxiety or depression are the main emotions or whether they coexist without any clear predominance; consequently, we hypothesize the existence of "specific transdiagnostic" mechanisms.