THE DROSOPHILA EXTRAMACROCHAETAE LOCUS, AN ANTAGONIST OF PRONEURAL GENES THAT, LIKE THESE GENES, ENCODES A HELIX-LOOP-HELIX PROTEIN
THE DROSOPHILA EXTRAMACROCHAETAE LOCUS, AN ANTAGONIST OF PRONEURAL GENES THAT, LIKE THESE GENES, ENCODES A HELIX-LOOP-HELIX PROTEIN
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DOI：
10.1016/0092-8674(90)90213-x
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发表时间：
1990-04-06
期刊：
影响因子：
64.5
通讯作者：
MODOLELL, J
中科院分区：
文献类型：
--
作者：
GARRELL, J;MODOLELL, J
果蝇外巨毛（emc）基因座通过以一种机制未知的方式拮抗刺毛-盾壳复合体（AS-C）的神经原性活动来参与感觉器官模式。我们克隆的emc DNA和emc突变的分子定位已经确定了一个转录单位作为最有可能的候选人的emc功能。它编码的蛋白质具有二聚螺旋-环-螺旋（HLH）基序，但缺乏一个可能对DNA结合重要的碱性区域。AS-C和其他原神经蛋白具有这两个结构域。我们建议，电磁兼容产品拮抗神经隔离前神经蛋白质的复合物效率低下的DNA相互作用。这些和其他研究结果表明，存在一个网络的协同和拮抗作用，介导的HLH蛋白，参与建立的神经命运。
The Drosophila extramacrochaetae (emc) locus participates in sensory organ patterning by antagonizing, in a mechanistically unknown way, the neurogenic activity of the achaete-scute complex (AS-C). Our cloning of emc DNA and molecular mapping of emc mutations have identified a transcription unit as the most likely candidate for the emc function. It encodes a protein that has a dimerizing helix-loop-helix (HLH) motif but lacks a basic region presumably important for DNA binding. AS-C and other proneural proteins have both domains. We propose that the emc product antagonizes neurogenesis by sequestering proneural proteins in complexes inefficient for DNA interaction. These and other findings suggest the existence of a network of synergistic and antagonistic interactions, mediated by HLH proteins, that participates in the establishment of the neural fate.