Intranuclear cytoplasmic inclusion is a significant diagnostic feature for the differentiation of lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma of the cervix
Intranuclear cytoplasmic inclusion is a significant diagnostic feature for the differentiation of lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma of the cervix
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DOI：
10.1002/dc.20859
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发表时间：
2008-08-01
影响因子：
1.3
通讯作者：
Hoshi, Kazuhiko
中科院分区：
文献类型：
--
作者：
Hashi, Akihiko;Yuminamochi, Tsutomu;Hoshi, Kazuhiko
小叶性颈内腺增生（LEGH）是一种伴有幽门腺化生的宫颈病变。宫颈微偏腺癌（MDA）是宫颈腺癌（AC）的一种分化非常好的类型。到目前为止，很难区分LEGH和MDA，因为它们具有相似的临床、放射学和免疫组化特征。此外，LEGH和MDA的细胞学特征尚未得到很好的定义。在本研究中，我们描述了LEGH和MDA的细胞学特征。我们回顾了24例宫颈LEGH（18例单纯型和6例混合型）和4例MDA病例。共审查了28例患者的40份细胞学涂片。丰富的黄色粘蛋白经常出现在LEGH和MDA中，然而，在24例LEGH病例中的22例中发现了INCI，并且在与LEGH相关的MDA或腺癌细胞中未发现INCI。在LEGH中未观察到细胞突起或结构变形。在MDA中，观察到轻微的细胞肿胀、三维不规则的细胞簇和显著的核仁。INCI的存在是诊断LEGH的良好参数。细胞学检查是LEGH与MDA鉴别的有效辅助手段。
Lobular endocervical glandular hyperplasia (LEGH) is a cervical lesion with pyloric gland metaplasia. Minimal deviation adenocarcinoma (MDA) is an extremely well differentiated form of endocervical adenocarcinoma (AC). To date, it is difficult to differentiate LEGH from MDA because they share similar clinical, radiological, and immunohistochemical features. Furthermore, the cytological features of LEGH and MDA have not been well defined. In the present study, we describe the cytological features of LEGH and MDA. We reviewed 24 cases of LEGH (18 pure and six mixed forms) and four MDA cases of the cervix. A total of 40 cytologic smears from 28 patients were reviewed. Abundant yellow mucin was frequently present in both LEGH and MDA; however, an INCI was found in 22 of the 24 LEGH cases and it was not found in either MDA or adenocarcinoma cells associated with LEGH. Neither cell atypia nor architectural distortion was observed in LEGH. In MDA, slight cellular atypia, three dimensional, irregular cell clustering, and prominent nucleoli were observed. The presence of an INCI is a good parameter for the diagnosis of LEGH. Cytology is an effective aid in the differentiation of LEGH from MDA.