DRUG-INDUCED REINSTATEMENT OF EXTINGUISHED SELF-ADMINISTRATION BEHAVIOR IN MONKEYS
DRUG-INDUCED REINSTATEMENT OF EXTINGUISHED SELF-ADMINISTRATION BEHAVIOR IN MONKEYS
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DOI：
10.1016/0091-3057(75)90016-7
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发表时间：
1975-01-01
影响因子：
3.6
通讯作者：
STRETCH, R
中科院分区：
文献类型：
--
作者：
GERBER, GJ;STRETCH, R
响应建立在松鼠猴（Saimiri seiureus）下的静脉注射D-苯丙胺或可卡因自我管理的改进的渐进比例时间表。用生理盐水替代药物溶液导致自我给药行为消失。静脉注射一定剂量的d-安非他明或可卡因，在测试会议之前立即响应视情况而定的盐水输注，恢复了在药物自我管理的会议期间观察到的响应率和模式。预先静脉注射几个剂量的戊巴比妥或氯丙嗪未能持续恢复反应。这些结果被解释为受试者当前药物状态对药物自我给药行为的区别性控制。
Responding was established in squirrel monkeys (Saimiri seiureus) under a modified progressive ratio schedule of i.v. d-amphetamine or cocaine self-administration. Substitution of saline for the drug solutions resulted in extinction of the self-administration behavior. I.v. injections of certain doses of d-amphetamine or cocaine, immediately prior to test sessions in which response-contingent saline infusions were delivered, reinstated the rate and pattern of responding observed during sessions in which drug was self-administered. Presession i.v. injections of several doses of pentobarbital or chlorpromazine failed to consistently reinstate responding. These results were interpreted in terms of the discriminative control of drug self-administration behavior by the current drug state of the subject.