Changes in regional gray and white matter volume in patients with myofascial-type temporomandibular disorders: a voxel-based morphometry study.
Changes in regional gray and white matter volume in patients with myofascial-type temporomandibular disorders: a voxel-based morphometry study.
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发表时间：
2011
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通讯作者：
G. Gerstner;E. Ichesco;A. Quintero;T. Schmidt-Wilcke
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作者：
G. Gerstner;E. Ichesco;A. Quintero;T. Schmidt-Wilcke
目的利用磁共振成像（MRI）和基于体素的形态测量学（VBM）寻找颞下颌关节紊乱病（TMD）患者脑形态学改变的证据。方法应用VBM技术，对9例TMD患者和9例健康对照者的局部灰质和白色物质体积进行了研究。结果TMD患者左侧扣带回前部、右侧扣带回后部、右侧岛叶前部、左侧额下回及双侧上级颞回灰质体积减少。此外，白色物质分析显示，TMD患者双侧内侧前额叶皮质区域白色物质体积减少。结论TMD与其他慢性疼痛状态一样，与中枢疼痛系统相关脑区的脑形态学改变有关，这些数据支持了以前的研究结果。
AIMS To use magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to search for evidence of altered brain morphology in patients with temporomandibular disorders (TMD). METHODS Using VBM, regional gray and white matter volume was investigated in nine TMD patients and nine carefully matched healthy controls. RESULTS A decrease in gray matter volume occurred in the left anterior cingulate gyrus, in the right posterior cingulate gyrus, the right anterior insular cortex, left inferior frontal gyrus, as well as the superior temporal gyrus bilaterally in the TMD patients. Also, white matter analyses revealed decreases in regional white matter volume in the medial prefrontal cortex bilaterally in TMD patients. CONCLUSION These data support previous findings by showing that TMD, like other chronic pain states, is associated with changes in brain morphology in brain regions known to be part of the central pain system.