Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus.
Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus.
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产前类固醇会降低羊胎儿的血脑屏障通透性。
DOI：
10.1152/ajpregu.1999.276.2.r283
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Patlak,CS
中科院分区：
文献类型：
--
作者：
Stonestreet,BS;Petersson,KH;Sadowska,GB;Pettigrew,KD;Patlak,CS
Antenatal corticosteroid therapy reduces the incidence of intraventricular hemorrhage in premature infants. Enhanced microvascular integrity might provide protection against intraventricular hemorrhage. In the adult, there is evidence to suggest that the blood-brain barrier may be under hormonal control. We hypothesized that antenatal corticosteroids decrease blood-brain barrier permeability in the preterm ovine fetus. Chronically instrumented 120-day-gestation fetuses were studied 12 h after the last of four 6-mg dexamethasone (n= 5) or placebo (n= 6) injections had been given over 48 h to the ewes. Blood-brain barrier function was quantified with the blood-to-brain transfer constant (Ki) for α-aminoisobutyric acid (AIB).Kiwas significantly lower across brain regions in the fetuses of ewes that received antenatal dexamethasone compared with placebo (ANOVA; interaction,F= 2.54,P< 0.004). In fetuses of dexamethasone- and placebo-treated ewes,Ki(μl ⋅ g brain wt−1⋅ min−1, mean ± SD) was, respectively, 2.43 ± 0.27 vs. 3.41 ± 0.74 in the cortex, 4.46 ± 0.49 vs. 5.29 ± 0.85 in the cerebellum, and 3.70 ± 0.49 vs. 5.11 ± 0.70 in the medulla. We conclude that antenatal treatment with corticosteroids reduces blood-brain permeability in the ovine fetus.
