The predictive value of procalcitonin for early detection of infection in elderly type 2 diabetes mellitus
The predictive value of procalcitonin for early detection of infection in elderly type 2 diabetes mellitus
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降钙素原对老年2型糖尿病早期感染的预测价值
DOI：
10.1016/j.jiac.2019.10.015
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发表时间：
2020-04-01
影响因子：
2.2
通讯作者：
Shi, Songchang
中科院分区：
文献类型：
--
作者：
Lin, Wei;Huang, Huibin;Shi, Songchang
目的：探讨降钙素原（procalcitonin， PCT）在老年2型糖尿病患者早期感染检测中的预测价值，并探讨PCT的最佳临界值。方法：回顾性研究伴有肺部感染（LI）、尿路感染（UTI）或皮肤软组织感染（SSTI）的2型糖尿病患者（>= 65岁）。构建3种标志物（PCT、WBC计数、CRP）的受试者工作特征（ROC）曲线，比较其诊断的准确性。结果：LI组、UTI组、SSTI组PCT的ROC曲线下面积（AUC）为0.98(95%可信区间（CI）： 0.96 ~ 0.99, p < 0.05)， UTI组为0.98 (95% CI: 0.96 ~ 0.99, p < 0.05)， SSTI组为0.97 （95% CI: 0.94 ~ 1.00, p < 0.05）。LI组PCT水平的最佳临界值为0.73 ng/mL (Sn 89.7%, Sp 97.7%)， UTI组为1.48 ng/mL (Sn 88.9%, Sp 100%)， SSTI组为0.73 ng/mL （Sn 85.7%, Sp 97.7%）。结论：PCT与各感染类型相关性最强，具有重要的诊断价值。老年糖尿病患者PCT水平的最佳分界点较高。(c) 2019年日本化疗学会和日本传染病协会。Elsevier Ltd.出版。版权所有。
Objective: Aimed to investigate the predictive value of procalcitonin (PCT) in early detection of infections in elderly patients with type 2 diabetes, and to discover the optimum cut-off points of PCT.Methods: A retrospective study was conducted with type 2 diabetic patients (>= 65 years) with lung infection (LI), urinary tract infection (UTI) or skin and soft tissue infection (SSTI). The receiver operating characteristic (ROC) curves of the 3 markers (PCT, WBC count, and CRP) were constructed and compared to assess their accuracies in diagnosing.Results: Among the three different groups with LI, UTI or SSTI, the area under the ROC curve (AUC) of PCT was 0.98 (95% confidence interval (CI): 0.96-0.99, p < 0.05) for the LI group, 0.98 (95% CI: 0.96-0.99, p < 0.05) for the UTI group, and 0.97 (95% CI: 0.94-1.00, p < 0.05) for the SSTI group. The optimum cutoff point of PCT level was 0.73 ng/mL (Sn 89.7%, Sp 97.7%) for the LI group, 1.48 ng/mL (Sn 88.9%, Sp 100%) for the UTI group, and 0.73 ng/mL (Sn 85.7%, Sp 97.7%) for the SSTI group.Conclusion: PCT demonstrated the strongest correlation with each of the infection types, indicating significant diagnostic value. Optimum cut-off points of PCT levels in elderly diabetes were higher. (c) 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.