Genomics meets transgenics in search of the elusive Cryptosporidium drug target.
Genomics meets transgenics in search of the elusive Cryptosporidium drug target.
复制标题
基因组学与转基因技术相结合，寻找难以捉摸的隐孢子虫药物靶点。
DOI：
10.1016/j.pt.2004.06.003
复制
发表时间：
2004
影响因子：
9.6
通讯作者：
Kissinger,JessicaC
中科院分区：
文献类型：
--
作者：
Striepen,Boris;Kissinger,JessicaC
隐孢子虫是一种重要的人类病原体，也是一种具有挑战性的实验室模型。寄生虫基因组序列可通过一个全面的数据库获得，现在为迫切需要的进展提供了令人兴奋的机会。比较基因组学与相关寄生虫刚地弓形虫的遗传系统相结合，勾勒出了详细的小隐孢子虫代谢图谱，并促进了细胞生物学分析。基于这种方法可以确定和验证隐孢子虫药物和疫苗开发的新靶点。
Cryptosporidiumis an important pathogen of humans, and a challenging model for the laboratory. The parasite genome sequence, accessible through a comprehensive database, now provides exciting opportunities for urgently needed advances. Comparative genomics, combined with the genetic system in the related parasiteToxoplasma gondii, outlines a detailedCryptosporidium parvummetabolic map and facilitates cell biological analyses. New targets forCryptosporidiumdrug and vaccine development can be identified and validated based on this approach.