Laminar pattern of adolescent development changes in working memory neuronal activity.
Laminar pattern of adolescent development changes in working memory neuronal activity.
复制标题
工作记忆神经元活动的青少年发育变化的层状模式。
DOI：
10.1152/jn.00294.2023
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发表时间：
2023
影响因子：
2.5
通讯作者：
Constantinidis,Christos
中科院分区：
文献类型：
--
作者：
Zhu,Junda;Hammond,BenjaminM;Zhou,XinMaizie;Constantinidis,Christos
青少年发展的特点是认知能力的提高，例如工作记忆。非人灵长类青春期模型的神经生理学记录揭示了神经活动的变化，反映了行为的改善，包括工作记忆任务延迟间隔期间更高的放电率。这些变化的层状分布尚不清楚。根据一些说法，持续活动在浅层更为明显，因此我们试图确定那里的变化是否最明显。因此，我们分析了雄性猴子幼年和成年阶段不同皮质深度的神经生理学记录。浅层在成年阶段表现出基线放电率增加。出乎意料的是，我们还检测到青春期后中层延迟期活动的大幅增加，即使在排除脑沟附近的渗透后也证实了这一点。最后，在眼跳周期周围的辨别能力的提高在更深的层中最为明显。这些结果揭示了与认知改善相关的神经活动成熟的层状模式。新的和值得注意的大脑结构变化在青少年发育过程中很明显，特别是前额皮质的皮质厚度，此时工作记忆能力显着增加。青春期神经生理变化的深度分布尚不清楚。在这里，我们表明神经生理学变化并不局限于浅层，而浅层通常与工作记忆的维持有关。与预期相反，前额皮质的中间层发生了明显的变化。
Adolescent development is characterized by an improvement in cognitive abilities, such as working memory. Neurophysiological recordings in a nonhuman primate model of adolescence have revealed changes in neural activity that mirror improvement in behavior, including higher firing rate during the delay intervals of working memory tasks. The laminar distribution of these changes is unknown. By some accounts, persistent activity is more pronounced in superficial layers, so we sought to determine whether changes are most pronounced there. We therefore analyzed neurophysiological recordings from the young and adult stage of male monkeys, at different cortical depths. Superficial layers exhibited an increased baseline firing rate in the adult stage. Unexpectedly, we also detected substantial increases in delay period activity in the middle layers after adolescence, which was confirmed even after excluding penetrations near sulci. Finally, improved discriminability around the saccade period was most evident in the deeper layers. These results reveal the laminar pattern of neural activity maturation that is associated with cognitive improvement.NEW & NOTEWORTHYStructural brain changes are evident during adolescent development particularly in the cortical thickness of the prefrontal cortex, at a time when working memory ability increases markedly. The depth distribution of neurophysiological changes during adolescence is not known. Here, we show that neurophysiological changes are not confined to superficial layers, which have most often been implicated in the maintenance of working memory. Contrary to expectations, substantial changes were evident in intermediate layers of the prefrontal cortex.