Localization of spontaneously hyperactive B cells of NZB mice to a specific B cell subset.
Localization of spontaneously hyperactive B cells of NZB mice to a specific B cell subset.
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NZB 小鼠自发性过度活跃 B 细胞定位于特定 B 细胞亚群。
DOI：
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发表时间：
1979
影响因子：
11.1
通讯作者：
Brigitte T. Huber
中科院分区：
文献类型：
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作者：
Pamela B. Nakajima;S. K. Datta;Robert S. Schwartz;Brigitte T. Huber
NZ B小鼠产生许多自身抗体，并且具有以IgM的显著自发性高分泌为特征的B细胞亚群。后者性状是由常染色体基因，在F1杂交NZB和正常株。我们通过检查（CBA/N X NZ B）F1杂交种来检验NZ B小鼠的高分泌B细胞包含在特定亚群中的假设。CBA/N小鼠具有X连锁隐性缺陷，其导致功能上不同的B细胞亚群的缺乏和受损的抗体应答。NZ B亲本特有的B细胞高活性遗传给F1代雌性，而F1代雄性不表达，表现为CBA/N B细胞低反应性。相比之下，NZB异嗜性病毒在雄性和雌性F1小鼠中表达相等。我们得出结论，NZ B B细胞异常存在于受CBA/N突变影响的B细胞亚群中。
NZB mice produce numerous autoantibodies and have a subpopulation of B cells characterized by marked spontaneous hypersecretion of IgM. The latter trait is determined by autosomal genes, in F1 hybrids of NZB and normal strains. We tested the hypothesis that the hypersecreting B cells of NZB mice are contained within a specific subpopulation by examining (CBA/N X NZB)F1 hybrids. CBA/N mice have an X-linked recessive defect that results in the absence of a functionally distinct B cell subpopulation and impaired antibody responses. The hyperactivity of B cells, characteristic of the NZB parent, was transmitted to the F1 female, but was not expressed by the F1 male, which manifested the CBA/N B cell hyporesponsiveness. By contrast, the NZB xenotropic virus was expressed equally by both male and female F1 mice. We conclude that the NZB B cell abnormality resides within the B cell subpopulation affected by the CBA/N mutation.