Preparation of ROS-responsive drug-loaded hydrogels applied in wound dressings using supercritical solvent impregnation
Preparation of ROS-responsive drug-loaded hydrogels applied in wound dressings using supercritical solvent impregnation
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超临界溶剂浸渍制备ROS响应性载药水凝胶应用于伤口敷料
DOI：
10.1016/j.supflu.2022.105682
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发表时间：
2022-07
影响因子：
3.9
通讯作者：
Shan-Jing Yao
中科院分区：
文献类型：
--
作者：
Jin-Zhou Rui;Hu-Hong Peng;Yi-Xin Guan;Shan-Jing Yao
具有创伤环境刺激反应特性的载药水凝胶能显著促进伤口愈合，在敷料中得到广泛应用。用3-氨基苯基硼酸对两种天然聚合物海藻酸钠和透明质酸钠进行改性，然后与聚乙烯醇进行交联，制备了ROS响应性水凝胶。采用超临界溶剂浸渍(SSI)技术将盐酸多西环素负载到水凝胶上，考察了浸泡时间、压力和温度对载药量的影响。DLC随超临界CO2压力的升高呈先增大后减小的趋势，在15 Mpa、50°C时，DLC最高可达11 mg/g。在体外释药研究中，通过硼酸酯键对ROS的敏感性，将盐酸多西环素从水凝胶中控制释放10h。本工作拓展了SSI在创面敷料中的应用，为药物分布均匀的复合水凝胶制剂的设计提供了新的途径。·通过交联Alg-PBA、HA-PBA和PVA制备了ROS响应型水凝胶。·使用超临界溶液浸渍将Doxy负载到水凝胶上。·载药水凝胶的动态力学性能可以调整。·DUG负载的水凝胶具有优异的体外抗菌性能。
Drug-loaded hydrogels with wound environment stimuli-responsive property can significantly promote wound healing and are widely applied in dressings. Two natural polymers, i.e. sodium alginate and sodium hyaluronate, were modified by 3-aminophenylboric acid and then cross-linked with polyvinyl alcohol to prepare ROS responsive hydrogels. Doxycycline hydrochloride was loaded onto hydrogels using supercritical solvent impregnation (SSI) technology, and the effects of immersion time, pressure and temperature on drug loading capacity (DLC) were investigated. DLC firstly increased and then decreased with the elevation of supercritical CO 2 pressure, and maximum value was up to 11 mg/g at 15 MPa and 50 °C. In the in vitro drug release study, doxycycline hydrochloride was controllably released from hydrogels for 10 h via the sensitivity of boronate ester bonds to ROS. This work expands the application of SSI in wound dressing, which provides a new approach for the design of composite hydrogel formulations with uniform drug distribution. • ROS-responsive hydrogels were fabricated via crosslinking Alg-PBA, HA-PBA and PVA. • Doxy was loaded onto hydrogels using supercritical solution impregnation. • The dynamic mechanical properties of drug-loaded hydrogels can be adjusted. • Dug-loaded hydrogels exhibited excellent in vitro antibacterial properties.
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