Enzymatic Oxidation of Alkyl Sulfides by Cytochrome P-450 and Hydroxyl Radical
Enzymatic Oxidation of Alkyl Sulfides by Cytochrome P-450 and Hydroxyl Radical
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细胞色素 P-450 和羟基自由基对烷基硫醚的酶促氧化
DOI：
10.1246/bcsj.54.1163
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发表时间：
1981
影响因子：
4
通讯作者：
S. Ōae
中科院分区：
文献类型：
--
作者：
Y. Watanabe;T. Numata;T. Iyanagi;S. Ōae
用兔肝微粒体或含有纯化细胞色素P-450的重构系统检查了烷基硫化物、亚砜和砜的氧化，发现带有较高酸性α-氢的烷基硫化物更容易发生S-脱烷基化。用羟基自由基氧化烷基硫醚得到了类似的结果。推测S-脱烷基化和S-氧化产物均通过阳离子自由基中间体形成。
The oxidation of alkyl sulfides, sulfoxides, and sulfones was examined with either rabbit liver microsomes or a reconstituted system containing purified cytochrome P-450, S-dealkylation being found to take place more readily with alkyl sulfides bearing a higher acidic α-hydrogen. Similar results were obtained in the oxidation of alkyl sulfides by hydroxyl radical. Both S-dealkylation and S-oxygenation products are presumed to be formed via the cation radical intermediate.