A Population-Based Descriptive Atlas of Invasive Pneumococcal Strains Recovered Within the US During 2015-2016
A Population-Based Descriptive Atlas of Invasive Pneumococcal Strains Recovered Within the US During 2015-2016
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DOI：
10.3389/fmicb.2018.02670
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发表时间：
2018-11-19
影响因子：
5.2
通讯作者：
Pilishvili, Tamara
中科院分区：
文献类型：
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作者：
Beall, Bernard;Chochua, Sopio;Pilishvili, Tamara
自 2000 年在美国实施 7 价结合疫苗 (PCV7) 和 2010 年实施 13 价结合疫苗 (PCV13) 以来，侵袭性肺炎球菌疾病 (IPD) 已大大减少。我们使用全基因组测序 (WGS) 来预测表型性状（血清型、抗菌表型和菌毛决定簇）并确定多位点 2015 年至 2016 年期间，通过主动细菌核心监测恢复了 5334 个分离株（类似于 90% 的病例）的基因型。我们鉴定出 44 种血清型； 26 占分离株的 98%。 PCV13血清型（包括血清型6C）占1503个（28.2%）分离株，其中血清型3最常见（657/5334，12.3%），而血清型1和5未检出。 305 例分离自儿童
Invasive pneumococcal disease (IPD) has greatly decreased since implementation in the U.S. of the 7 valent conjugate vaccine (PCV7) in 2000 and 13 valent conjugate vaccine (PCV13) in 2010. We used whole genome sequencing (WGS) to predict phenotypic traits (serotypes, antimicrobial phenotypes, and pilus determinants) and determine multilocus genotypes from 5334 isolates (similar to 90% of cases) recovered during 2015-2016 through Active Bacterial Core surveillance. We identified 44 serotypes; 26 accounted for 98% of the isolates. PCV13 serotypes (inclusive of serotype 6C) accounted for 1503 (28.2%) isolates, with serotype 3 most common (657/5334, 12.3%), while serotypes 1 and 5 were undetected. Of 305 isolates from children