Superficial Enhanced Fluid Fat Injection (SEFFI) to Correct Volume Defects and Skin Aging of the Face and Periocular Region
Superficial Enhanced Fluid Fat Injection (SEFFI) to Correct Volume Defects and Skin Aging of the Face and Periocular Region
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DOI：
10.1093/asj/sjv001
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发表时间：
2015-07-01
影响因子：
2.9
通讯作者：
Quarto, Rodolfo
中科院分区：
文献类型：
--
作者：
Bernardini, Francesco P.;Gennai, Alessandro;Quarto, Rodolfo
尽管最近对微脂肪的研究显示了表面植入和高干细胞含量的潜在优势，本文报告了应用表面增强液体脂肪注射（SEFFI）治疗面部和眼周皮肤体积减少和老化的经验，SEFFI的制备方法越精细，治疗效果越好。方法：将0.5mL的注射液注入眶周和口周的眼轮匝肌内，将0.8mL的注射液注入面部其他部位的皮下。平均随访时间为6个月，0.5 mL和0.8 mL制剂的平均植入脂肪体积分别为20 mL和51.4 mL。所有患者的体积恢复和皮肤改善均达到良好或极佳的结果。并发症轻微，包括3例患者的油囊肿。较小的SEFFI数量（0.5mL）非常适合于矫正眼睑中的体积损失，尤其是深的上沟和泪槽，而较大的SEFFI含量对于面部的其他区域中的较大体积缺损有效，包括眉、颞窝、颧骨-颧骨区域、鼻唇沟、木偶纹、下巴、SEFFI管理的脂肪可以通过小型侧孔插管轻松采集，产生富含活性脂肪细胞和干细胞的微脂肪。两种体积的脂肪（0.5 mL和0.8 mL）都能有效治疗与年龄相关的脂肪萎缩，减少面部皱纹，改善皮肤质量。
Although recent research on micro fat has shown the potential advantages of superficial implantation and high stem cell content, clinical applications thus far have been limited.The authors report their experience with superficial enhanced fluid fat injection (SEFFI) for the correction of volume loss and skin aging of the face in general and in the periocular region.The finer SEFFI preparation (0.5 mL) was injected into the orbicularis in the periorbital and perioral areas, and the 0.8-mL preparation was injected subdermally elsewhere in the face.The records of 98 consecutive patients were reviewed. Average follow-up time was 6 months, and average volume of implanted fat was 20 mL and 51.4 mL for the 0.5-mL and 0.8-mL preparations, respectively. Good or excellent results were achieved for volume restoration and skin improvement in all patients. Complications were minor and included an oil cyst in 3 patients. The smaller SEFFI quantity (0.5 mL) was well suited to correct volume loss in the eyelids, especially the deep upper sulcus and tear trough, whereas the larger SEFFI content was effective for larger volume deficits in other areas of the face, including the brow, temporal fossa, zygomatic-malar region, nasolabial folds, marionette lines, chin, and lips.The fat administered by SEFFI is easily harvested via small side-port cannulae, yielding micro fat that is rich in viable adipocytes and stem cells. Both volumes of fat (0.5 mL and 0.8 mL) were effective for treating age-related lipoatrophy, reducing facial rhytids, and improving skin quality.4