ARACHIDONIC-ACID AND OTHER FATTY-ACIDS DIRECTLY ACTIVATE POTASSIUM CHANNELS IN SMOOTH-MUSCLE CELLS
ARACHIDONIC-ACID AND OTHER FATTY-ACIDS DIRECTLY ACTIVATE POTASSIUM CHANNELS IN SMOOTH-MUSCLE CELLS
复制标题
DOI：
10.1126/science.2471269
复制
发表时间：
1989-06-09
期刊：
影响因子：
56.9
通讯作者：
SINGER, JJ
中科院分区：
文献类型：
--
作者：
ORDWAY, RW;WALSH, JV;SINGER, JJ
花生四烯酸，以及不作为环氧合酶和脂氧合酶底物的脂肪酸，激活了新解离的平滑肌中一种特定类型的钾通道。在没有钙和所有核苷酸的情况下，激活发生在切除的膜斑块上。因此，需要这些可溶性因子的信号转导途径，包括nadph依赖性细胞色素P450途径，不介导反应。因此，脂肪酸直接激活钾通道，因此可能构成一类调节离子通道的信号分子。
Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the respose. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels.