Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia:: an open, uncontrolled pilot study
Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia:: an open, uncontrolled pilot study
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DOI：
10.1016/j.fertnstert.2003.05.009
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发表时间：
2004-01-01
影响因子：
6.7
通讯作者：
Littarru, G
中科院分区：
文献类型：
--
作者：
Balercia, G;Mosca, F;Littarru, G
目的：为了阐明辅酶Q（10）（CoQ（10））在特发性弱精子症不育男性中的潜在治疗作用。设计：开放、无对照的初步研究。患者：特发性弱精子症不育男性。干预：口服CoQ（10）;在基线和治疗6个月后收集精液样本。主要结果测量：精液动力学参数，包括计算机辅助精子数据和辅酶Q（10）和磷脂酰胆碱水平。磷脂酰胆碱水平也增加。计算机辅助分析证实，精子活力也显着增加。一个积极的依赖性（使用Cramer的关联指数）之间的相对变化，基线和治疗后，精浆或细胞内辅酶Q（10）含量和计算机确定的动力学参数是明显的。这可能是其在线粒体生物能量学中的作用及其抗氧化特性的结果。
Objective: To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia.Design: Open, uncontrolled pilot study.Patient(s): Infertile men with idiopathic asthenozoospermia.Intervention(s): CoQ(10) was administered orally; semen samples were collected at baseline and after 6 months of therapy.Main Outcome Measure(s): Semen kinetic parameters, including computer-assisted sperm data and CoQ(10) and phosphatidycholine levels.Result(s): CoQ(10) levels increased significantly in seminal plasma and in sperm cells after treatment. Phosphatidylcholine levels also increased. A significant increase was also found in sperm cell motility as confirmed by computer-assisted analysis. A positive dependence (using the Cramer's index of association) was evident among the relative variations, baseline and after treatment, of seminal plasma or intracellular CoQ(10) content and computer-determined kinetic parameters.Conclusion(s): The exogenous administration of CoQ(10) may play a positive role in the treatment of asthenozoospermia. This is probably the result of its role in mitochondrial bioenergetics and its antioxidant properties.