A neuroimaging study of premotor lateralization and cerebellar involvement in the production of phonemes and syllables.
A neuroimaging study of premotor lateralization and cerebellar involvement in the production of phonemes and syllables.
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DOI：
10.1044/1092-4388(2008/07-0119
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Guenther FH
中科院分区：
文献类型：
--
作者：
Ghosh SS;Tourville JA;Guenther FH
本研究探讨了参与元音、单音节词和双音节词的明显产生的大脑区域网络，以检验来自发音速度方向（DIVA）模型的假设。DIVA模型预测左偏侧活动时，产生一个单一的音节或音素和增加小脑活动的辅音-元音音节相比，稳态元音下额叶皮层。稀疏采样功能磁共振成像（fMRI）用于收集来自10名美国英语右撇子说话者的数据，同时产生孤立的单音节词（例如，“ba”、“oo”）。数据进行了分析，使用基于体素和参与者特定的解剖区域的兴趣为基础的技术。单音节词的明显产生激活了一个大脑区域网络，包括左腹侧运动前皮层、左后额下回、双侧辅助运动区、感觉运动皮层、听觉皮层、丘脑和小脑。Paravermal小脑表现出更大的活动辅音元音音节相比，元音。左侧运动前皮层活动的发现支持DIVA模型的预测，即该区域包含代表音节运动程序的细胞群，而不考虑语义内容。此外，与元音相比，上级小脑旁对辅音-元音音节更为活跃，这可能是由于辅音产生的时间限制增加。
This study investigated the network of brain regions involved in overt production of vowels, monosyllables, and bisyllables to test hypotheses derived from the Directions Into Velocities of Articulators (DIVA) model of speech production. The DIVA model predicts left lateralized activity in inferior frontal cortex when producing a single syllable or phoneme and increased cerebellar activity for consonant–vowel syllables compared with steady-state vowels. Sparse sampling functional magnetic resonance imaging (fMRI) was used to collect data from 10 right-handed speakers of American English while producing isolated monosyllables (e.g., “ba,” “oo”). Data were analyzed using both voxel-based and participant-specific anatomical region-of-interest–based techniques. Overt production of single monosyllables activated a network of brain regions, including left ventral premotor cortex, left posterior inferior frontal gyrus, bilateral supplementary motor area, sensorimotor cortex, auditory cortex, thalamus, and cerebellum. Paravermal cerebellum showed greater activity for consonant-vowel syllables compared to vowels. The finding of left-lateralized premotor cortex activity supports the DIVA model prediction that this area contains cell populations representing syllable motor programs without regard for semantic content. Furthermore, the superior paravermal cerebellum is more active for consonant–vowel syllables compared with vowels, perhaps due to increased timing constraints for consonant production.