Biological variation of hematology tests based on the 1999-2002 National Health and Nutrition Examination Survey.
Biological variation of hematology tests based on the 1999-2002 National Health and Nutrition Examination Survey.
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发表时间：
2012-07
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通讯作者：
D. Lacher;J. Barletta;Jeffery P. Hughes
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作者：
D. Lacher;J. Barletta;Jeffery P. Hughes
目的生物变异包括人与人之间的变异和人与人之间的变异。血液学实验室检查的WP变异系数（CVw）和BP变异系数（CVg）的估计值来自1999-2002年全国健康和营养检查调查（NHANES）。NHANES是一项针对美国非制度化平民人口的调查，采用分层，多阶段概率设计。估计了18项血液学检查的人与人之间的差异。对于WP变化，获得了两次测试测量之间中位数为17天的非随机样本。从WP样本中估计人与人之间的差异，并将其他参与者的年龄组、性别、种族和民族与WP样本相匹配。结果BP和WP的变化估计多达2496和852样本参与者，分别。平均红细胞血红蛋白浓度的CVg最低（男性为2.25%，女性为2.40%），平均红细胞体积的CVw最低（男性为0.31%，女性为0.37%）。个体性指数（CVw/CVg）的范围为0.06（男性和女性的平均红细胞体积）至0.62（男性的分叶核中性粒细胞数量）和0.55（女性的分叶核中性粒细胞百分比）。女性在红细胞压积、血红蛋白、平均红细胞体积、红细胞计数和红细胞分布宽度方面的CVw高于男性。几项血液学检查的CVw也因年龄组而异，包括平均红细胞体积;嗜酸性粒细胞、淋巴细胞和分叶核中性粒细胞百分比;单核细胞和分叶核中性粒细胞数量;白色血细胞计数;和红细胞分布宽度。
OBJECTIVE Biological variation consists of between-person (BP) and within-person (WP) variation. Estimates of WP coefficients of variation (CVw) and BP coefficients of variation (CVg) for hematology laboratory tests were estimated from the 1999-2002 National Health and Nutrition Examination Survey (NHANES). METHODS NHANES is a survey of the civilian noninstitutionalized U.S. population that uses a stratified, multistage probability design. Between- and within-person variations were estimated for 18 hematology tests. For WP variation, a nonrandom sample was obtained with a median of 17 days between two test measurements. Between-person variation was estimated from the WP sample and additional participants were matched for age group, gender, and race and ethnicity to the WP sample. RESULTS The BP and WP variations were estimated on as many as 2496 and 852 sample participants, respectively. Mean corpuscular hemoglobin concentration had the lowest CVg (2.25% for men and 2.40% for women), and mean corpuscular volume had the lowest CVw (0.31% for men and 0.37% for women). The index of individuality (CVw/CVg) ranged from 0.06 for mean corpuscular volume for men and women to 0.62 for segmented neutrophil number for men, and 0.55 for segmented neutrophil percent for women. Women had higher CVw compared with men for hematocrit, hemoglobin, mean corpuscular volume, red blood cell count, and red blood cell distribution width. Several hematology tests' CVw also differed by age group, including mean corpuscular volume; eosinophil, lymphocyte and segmented neutrophil percent; monocyte and segmented neutrophil number; white blood cell count; and red blood cell distribution width.