Associated clinical factors for serious infections in patients with systemic lupus erythematosus
Associated clinical factors for serious infections in patients with systemic lupus erythematosus
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DOI：
10.1038/s41598-019-46039-5
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发表时间：
2019-07-04
影响因子：
4.6
通讯作者：
Suh, Chang-Hee
中科院分区：
文献类型：
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作者：
Jung, Ju-Yang;Yoon, Dukyong;Suh, Chang-Hee
系统性红斑狼疮（SLE）患者常发生感染，是其发病和死亡的主要原因。然而，目前还没有大规模的综合性研究评估临床特征对实际临床实践中严重感染的影响。我们使用电子病历数据调查了临床特征对严重感染的影响。我们进行了巢式病例对照研究。发生严重感染需要住院或静脉注射抗生素的SLE患者（n = 120）与对照组（n = 240）相匹配。通过条件Logistic回归分析获得与临床特征相关的感染的优势比（OR）和95%置信区间（Os）。调整后的条件Logistic回归分析显示，浆膜炎（OR，2.76; 95%CI，1.33-5.74），血液学受累（OR，2.53; 95%CI，1.32-4.87），且使用高于低剂量的糖皮质激素（GC; >7.5 mg/d泼尼松龙当量）（OR，2.65; 95% CI，1.31-5.34）与SLE严重感染有关。浆膜炎、血液系统受累和使用高于低剂量的GCs与SLE患者的严重感染相关。
Infection occurs frequently in patients with systemic lupus erythematosus (SLE), and has been a major cause of morbidity and mortality. However, no large-scale comprehensive studies have estimated the effect of clinical characteristics on serious infection in actual clinical practice yet. We investigated the influence of clinical characteristics on serious infections using electronic medical records data. We conducted a nested case-control study. Patients with SLE who developed serious infection which needs hospitalization or intravenous antibiotics (n = 120) were matched to controls (n = 240) who didn't. Odds ratios (OR) and 95% confidence intervals (Os) for infection associated with clinical features were obtained by conditional logistic regression analyses. The conditional logistic regression analysis with adjustment showed that serositis (OR, 2.76; 95%CI, 1.33-5.74), hematologic involvement (OR, 2.53; 95% CI, 1.32-4.87), and use of higher than the low dose of glucocorticoids (GCs; >7.5 mg/d prednisolone-equivalent) (OR, 2.65; 95% CI, 1.31-5.34) were related to serious infections in SLE. Serositis, hematologic involvement, and use of higher than the low dose of GCs were associated with serious infections in patients with SLE.