Evidence for the contribution of muscle stem cells to nonhypertrophic skeletal muscle remodeling in humans
Evidence for the contribution of muscle stem cells to nonhypertrophic skeletal muscle remodeling in humans
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DOI：
10.1096/fj.13-229799
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发表时间：
2013-11-01
期刊：
影响因子：
4.8
通讯作者：
Parise, Gianni
中科院分区：
文献类型：
--
作者：
Joanisse, Sophie;Gillen, Jenna B.;Parise, Gianni
这项研究的目的是探索肌肉干细胞，也被称为卫星细胞(SCs)，在人类非肥厚性刺激后的适应和重塑中的可能作用。在有氧间歇训练前和训练后6wk，取未曾训练过的女性(n=15；年龄：27+/-8岁，体重指数：29+/-6 kg/m(2))股外侧肌活检。用免疫荧光显微镜对肌肉横截面的纤维类型特异性SC对训练的反应进行分析。训练后，与表达肌球蛋白重链I型和II型异构体(混合纤维)相关的干细胞数量增加(前：0.062+/-0.035 SC/混合纤维；后：0.38+/-0.063 SC/混合纤维；P
The purpose of this study was to explore the possible role of muscle stem cells, also referred to as satellite cells (SCs), in adaptation and remodeling following a nonhypertrophic stimulus in humans. Muscle biopsies were obtained from the vastus lateralis of previously untrained women (n=15; age: 27 +/- 8 yr, BMI: 29 +/- 6 kg/m(2)) before and after 6 wk of aerobic interval training. The fiber type-specific SC response to training was analyzed using immunofluorescent microscopy of muscle cross sections. Following training, the number of SCs associated with fibers expressing myosin heavy-chain type I and II isoforms (hybrid fibers) increased (pre: 0.062 +/- 0.035 SC/hybrid fiber; post: 0.38 +/- 0.063 SC/hybrid fiber; P