Chemokines and the arrest of lymphocytes rolling under flow conditions
Chemokines and the arrest of lymphocytes rolling under flow conditions
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DOI：
10.1126/science.279.5349.381
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发表时间：
1998-01-16
期刊：
影响因子：
56.9
通讯作者：
Butcher, EC
中科院分区：
文献类型：
--
作者：
Campbell, JJ;Hedrick, J;Butcher, EC
循环淋巴细胞通过沿着内皮细胞，直到被与异源三聚体GTP结合蛋白的G（i）α亚基连接的信号传导事件停止，从血液中募集到组织中;该事件然后触发快速的整合素依赖性粘附。四种趋化因子现在显示出诱导这种粘附tb细胞间粘附分子-1，并在类似于血液的流动条件下诱导滚动细胞在1秒内停滞。SDF-1（也称为PBSF）、6-C-kine（也称为Exodus-2）和MIP-3 β（也称为ELC或Exodus-3）诱导大多数循环淋巴细胞的粘附，包括大多数CD 4（+）T细胞; MIP-3 α（也称为LARC或Exodus-1）触发记忆性CD 4（+）T细胞的粘附，但不触发幼稚性CD 4（+）T细胞的粘附。因此，趋化因子可以调节淋巴细胞亚群在有缺陷条件下的停滞，这可能使它们能够控制淋巴细胞-内皮细胞识别和体内淋巴细胞募集。
Circulating lymphocytes are recruited from the blood to the tissue by railing along the endothelium until being stopped by a signaling event linked to the G(i) alpha subunit of a heterotrimeric GTP-binding protein; that event then triggers rapid integrin-dependent adhesion. Four chemokines are now shown to induce such adhesion tb intercellular adhesion molecule-1 and to induce arrest of rolling cells within 1 second under flow conditions similar to those of blood. SDF-1 (also called PBSF), 6-C-kine (also called Exodus-2), and MIP-3 beta (also called ELC or Exodus-3) induced adhesion of most circulating lymphocytes, including most CD4(+) T cells; and MIP-3 alpha (also called LARC or Exodus-1) triggered adhesion of memory, but not nai ve, CD4(+) T cells. Thus, chemokines can regulate the arrest of lymphocyte subsets under flawing conditions, which may allow them to control lymphocyte-endothelial cell recognition and lymphocyte recruitment in vivo.