Hypertension and kidney damage.
Hypertension and kidney damage.
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DOI：
10.1111/j.1524-6175.2005.05111.x
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发表时间：
2006-03-01
期刊：
影响因子：
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通讯作者：
Griffin, Karen A
中科院分区：
文献类型：
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作者：
Griffin, Karen A
大量证据表明，高血压是大多数患者发生终末期肾病的主要原因。然而，这种风险范围从原发性高血压相当低到慢性肾脏疾病（包括糖尿病肾病）患者对高血压损伤的易感性显著增加。在实验动物模型中使用血压无线电遥测的研究提供了重要的见解，血压和肾损伤之间的定量关系和重要性的保护性肾自动调节能力作为高血压损伤易感性的决定因素。此外，这些研究还强调了在减缓慢性肾脏疾病进展方面，达到正常血压本身比选择特定的抗高血压方案（包括肾素-血管紧张素系统阻断剂）更为重要。
Substantial evidence indicates that hypertension is a major contributor to the development of end-stage renal disease in most patients. However, such risk ranges from being fairly low in essential hypertension to a marked increase in susceptibility to hypertensive injury in patients with chronic kidney disease, including diabetic nephropathy. Studies in experimental animal models using blood pressure radiotelemetry have provided significant insights into the quantitative relationships between blood pressure and renal damage and the importance of protective renal autoregulatory capacity as a determinant of such differences in susceptibility to hypertensive injury. Moreover, such investigations have also emphasized the predominant importance of achieving normotension per se over the selection of particular antihypertensive regimens, including renin-angiotensin system blockade, in slowing the progression of chronic kidney disease.