Tube formation in Drosophila egg chambers
Tube formation in Drosophila egg chambers
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DOI：
10.1089/ten.tea.2008.0124
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发表时间：
2008-09-01
影响因子：
4.1
通讯作者：
Berg, Celeste A.
中科院分区：
文献类型：
--
作者：
Berg, Celeste A.
上皮层重组成管是许多器官形成的基本过程，如肺、肾、肠和神经管。这个过程涉及不同细胞类型的图案化以及这些细胞在产生管的形状变化和重排期间的协调。更好地理解调控管形成的细胞和遗传机制对于组织工程师在体外发育功能器官是必要的。果蝇卵室已成为研究微管发生的一个杰出模型。由滤泡上皮合成的背侧呼吸附属物类似于脊椎动物的初级神经形成。这篇综述总结了背附件管的图案和形态发生的工作，并强调了数学建模有助于我们理解这些过程的关键领域。
The reorganization of epithelial sheets into tubes is a fundamental process in the formation of many organs, such as the lungs, kidneys, gut, and neural tube. This process involves the patterning of distinct cell types and the coordination of those cells during the shape changes and rearrangements that produce the tube. A better understanding of the cellular and genetic mechanisms that regulate tube formation is necessary for tissue engineers to develop functional organs in vitro. The Drosophila egg chamber has emerged as an outstanding model for studying tubulogenesis. Synthesis of the dorsal respiratory appendages by the follicular epithelium resembles primary neurulation in vertebrates. This review summarizes work on the patterning and morphogenesis of the dorsal-appendage tubes and highlights key areas where mathematical modeling could contribute to our understanding of these processes.