Unraveling MCL-1 degradation
Unraveling MCL-1 degradation
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DOI：
10.1038/sj.cdd.4401978
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发表时间：
2006-08-01
影响因子：
12.4
通讯作者：
Opferman, J. T.
中科院分区：
文献类型：
--
作者：
Opferman, J. T.
生长因子信号调节细胞在发育和动态平衡过程中的生长和存活。BCL-2家族蛋白是位于细胞死亡不可逆转的上游的凋亡途径中的关键控制点，其成员通过调节线粒体外膜通透性来控制线粒体中的促凋亡因子的释放。Mauer等人最近的一篇文章(Mol.Cell21：749-760,2006)提供了令人信服的证据，表明生长因子信号的一个重要作用是它调节关键的抗凋亡bcl2家族成员mcl1的蛋白质稳定性。
Growth factor signaling regulates the growth and survival of cells during development and homeostasis. The BCL-2 family of proteins represents a critical control point in the apoptotic pathway residing upstream to irreversible commitment to cell death, where its members control the release of apoptogenic factors from the mitochondria by regulating mitochondrial outer membrane permeabilization. A recent article by Mauer et al.(Mol. Cell 21: 749-760, 2006) provides convincing evidence that one important role of growth factor signaling is its regulation of the protein stability of the critical antiapoptotic BCL-2 family member, MCL-1.