Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
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DOI：
10.1097/ypg.0b013e32809913d8
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发表时间：
2007-08-01
影响因子：
0.9
通讯作者：
Arinami, Tadao
中科院分区：
文献类型：
--
作者：
Iwasaki, Shinya;Ishiguro, Hiroki;Arinami, Tadao
研究背景脂肪酸酰胺水解酶和甘油单酯脂肪酶是内源性大麻素的主要代谢酶。由于内源性大麻素系统在成瘾中的重要性，目的探讨日本人群中脂肪酸酰胺水解酶和单甘酯脂肪酶基因的单核苷酸多态性与酒精中毒的关系。对729名日本酒精中毒患者和799名健康对照者进行了这两个基因中总共14个标签单核苷酸多态性的对照研究。基因型和等位基因频率进行了比较，这些groups.Results之间的这些遗传标记，但是，没有表现出显着的关联与酒精中毒在Japanese.Conclusion，而我们研究了酒精中毒和标签单核苷酸多态性，涵盖了这些内源性大麻素代谢酶基因的大部分区域之间的关联在一个更大的样本量，我们发现，这些都没有相关的易感性，在日本人口酒精中毒。
Background Fatty acid amide hydrolase and monoglyceride lipase are the major endocannabinoid metabolic enzymes. Owing to the importance of endocannabinoid system in addiction, the Pro129Thr polymorphism in the fatty acid amid hydrolase gene has reportedly been associated with substance abuse and dependence in a Caucasian population.Objective To determine whether the single nucleodtide polymorphisms of the fatty acid amid hydrolase and monoglyceride lipase genes are associated with alcoholism in a Japanese population.Methods We conducted case-control studies for total 14 tag single nucleotide polymorphisms in those two genes using 729 Japanese patients with alcoholism and 799 healthy controls. Genotype and allele frequencies were compared between these groups.Results None of these genetic markers, however, showed significant association with alcoholism in Japanese.Conclusion Whereas we examined associations in a larger sample size between alcoholism and tag single nucleotide polymorphisms that covered most regions of these endocannabinoid metabolic enzyme genes, we found that these are not associated with susceptibility to alcoholism in a Japanese population.