Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia
Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia
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DOI：
10.3390/app11146637
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发表时间：
2021-07-01
影响因子：
2.7
通讯作者：
El-Gendy, Ahmed A.
中科院分区：
文献类型：
--
作者：
Sanad, Mohamed F.;Meneses-Brassea, Bianca P.;El-Gendy, Ahmed A.
今天，磁热疗法是癌症治疗的一种补充方法。本文报道了磁性热疗解决超顺磁性和高铁/金核壳纳米粒子的一个有前途的方面。这些纳米颗粒是在室温下用湿化学方法制备的。我们发现合成的核壳以球形形态组装，包括面心立方包覆的铁核和金核。高分辨率透射电镜（HRTEM）显示了Fe/Au核/壳纳米颗粒的形成。样品的磁性表现为磁滞回线，矫顽力（HC）接近于零，在室温下表现出超顺磁性。当铁金比为2:1时，合成样品的饱和磁化强度（MS）为165 emu/g。我们还研究了核壳粒子在不同频率和不同外加交变磁场下用于磁热疗的可行性。在振幅为400 Oe、频率为304 kHz的交变磁场作用下，Fe/Au核壳纳米粒子的比吸收率为50 W/g。根据我们的发现，这些样品可以作为磁性热疗治疗癌症的有希望的候选者。
Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperature. We found that the as-synthesized core shells assembled with spherical morphology, including face-centered-cubic Fe cores coated and Au shells. The high-resolution transmission microscope images (HRTEM) revealed the formation of Fe/Au core/shell nanoparticles. The magnetic properties of the samples showed hysteresis loops with coercivity (HC) close to zero, revealing superparamagnetic-like behavior at room temperature. The saturation magnetization (MS) has the value of 165 emu/g for the as-synthesized sample with a Fe:Au ratio of 2:1. We also studied the feasibility of those core-shell particles for magnetic hyperthermia using different frequencies and different applied alternating magnetic fields. The Fe/Au core-shell nanoparticles achieved a specific absorption rate of 50 W/g under applied alternating magnetic field with amplitude 400 Oe and 304 kHz frequency. Based on our findings, the samples can be used as a promising candidate for magnetic hyperthermia for cancer therapy.