Lack of evidence of avian-to-human transmission of avian influenza A (H5N1) virus among poultry workers, Kano, Nigeria, 2006
Lack of evidence of avian-to-human transmission of avian influenza A (H5N1) virus among poultry workers, Kano, Nigeria, 2006
复制标题
DOI：
10.1086/522158
复制
发表时间：
2007-12-01
影响因子：
6.4
通讯作者：
Wali, Sadiq S.
中科院分区：
文献类型：
--
作者：
Ortiz, Justin R.;Katz, Mark A.;Wali, Sadiq S.
背景。 2006年2月，尼日利亚证实家禽爆发高致病性甲型H5N1禽流感疫情。进行了一项血清调查，以评估尼日利亚家禽工作人员和实验室工作人员中 H5N1 的传播情况。方法。 2006年3月21日至4月3日，对295名疑似接触H5N1病毒的家禽工作人员和25名实验室工作人员进行了问卷调查，以评估H5N1病毒接触情况、病史和医疗保健利用情况。从参与者身上采集血清样本，通过微量中和试验检测 H5N1 中和抗体。结果。 295 名家禽工人报告称，在没有抗病毒化学预防且没有配备最低限度的个人防护装备的情况下，接触疑似或确诊感染 H5N1 的家禽的时间中位数为 14 天。 25名实验室工作人员中，均处理过疑似H5N1病毒感染的家禽标本。所有参与者的 H5N1 中和抗体检测均为阴性。结论。尽管广泛接触可能感染 H5N1 病毒的家禽，但在参与者中没有发现 H5N1 病毒感染的血清学证据。鉴于 H5N1 病毒继续在家禽中传播和进化，需要继续监测人类 H5N1 病例并进一步进行血清流行率调查，以评估禽类向人类传播的风险。
Background. In February 2006, poultry outbreaks of highly pathogenic avian influenza A (H5N1) virus were confirmed in Nigeria. A serosurvey was conducted to assess H5N1 transmission among poultry workers and laboratory workers in Nigeria.Methods. From 21 March through 3 April 2006, 295 poultry workers and 25 laboratory workers with suspected exposure to H5N1 virus were administered a questionnaire to assess H5N1 exposures, medical history, and health care utilization. A serum specimen was collected from participants to test for H5N1 neutralizing antibodies by microneutralization assay.Results. The 295 poultry workers reported a median of 14 days of exposure to suspected or confirmed H5N1-infected poultry without antiviral chemoprophylaxis and with minimal personal protective equipment. Among 25 laboratory workers, all handled poultry specimens with suspected H5N1 virus infection. All participants tested negative for H5N1 neutralizing antibodies.Conclusions. Despite widespread exposure to poultry likely infected with H5N1 virus, no serological evidence of H5N1 virus infection was identified among participants. Continued surveillance for H5N1 cases in humans and further seroprevalence investigations are needed to assess the risk of avian-to-human transmission, given that H5N1 viruses continue to circulate and evolve among poultry.