Clinical Efficacy of Antivenom and Cepharanthine for the Treatment. of Mamushi (Gloydius blomhoffii) Bites in Tertiary Care Centers in Japan
Clinical Efficacy of Antivenom and Cepharanthine for the Treatment. of Mamushi (Gloydius blomhoffii) Bites in Tertiary Care Centers in Japan
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DOI：
10.7883/yoken.66.26
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发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
Takahashi, Motohide
中科院分区：
文献类型：
--
作者：
Hifumi, Toru;Yamamoto, Akihiko;Takahashi, Motohide
据我们所知，还没有人进行过一项多中心试验来评估抗蛇毒血清和千金藤素 (CEP) 治疗 mamushi (Gloydius blomhoffii) 咬伤的疗效。因此，我们于2009年11月至2010年10月在日本三级医疗中心进行了一项大规模调查，以评估抗蛇毒血清和CEP治疗mamushi咬伤的疗效。我们将患者接受的治疗干预分为 4 组：CEP、抗蛇毒血清、CEP 和抗蛇毒血清、既不 CEP 又不抗蛇毒血清。我们收集了有关年龄、性别、合并症、实验室测量、住院时间和 mamushi 咬伤等级的数据（咬伤严重程度从 I [轻度] 到 V [重度]）。我们向 219 个三级医疗中心发送了问卷，其中 114 个（52.1%）返回了完整的问卷。据报道，有 234 起马穆什咬伤事件。在严重病例（mamushi 咬伤 III、IV 和 V 级）中，接受抗蛇毒血清的患者的住院时间明显短于接受 CEP 的患者（P = 0.024）。相比之下，轻症病例（mamushi咬伤I级和II级）之间的住院时间没有显着差异（P = 0.77）。我们的结果表明，抗蛇毒血清可有效缩短严重马木什咬伤患者的住院时间。
To our knowledge, no one has conducted a multi-center trial evaluating the efficacy of antivenom and cepharanthine (CEP) for the treatment of mamushi (Gloydius blomhoffii) bites. Thus, we conducted a large-scale survey among tertiary care centers in Japan from November 2009 to October 2010 to evaluate the efficacy of antivenom and CEP for the treatment of mamushi bites. We divided the therapeutic interventions received by patients into 4 groups: CEP, antivenom, both CEP and antivenom, and neither CEP nor antivenom. We collected data on age, sex, comorbidities, laboratory measurements, length of hospital stay, and grades of mamushi bites (indication of bite severity ranged from I [mild] to V [severe]). We sent questionnaires to 219 tertiary care centers, of which 114 (52.1%) returned completed questionnaires. Two hundred and thirty-four cases of mamushi bites were reported. Among the severe cases (grades of mamushi bites III, IV, and V), patients administered antivenom had a significantly shorter length of hospital stay than those administered CEP (P = 0.024). In contrast, there was no significant difference in the length of hospital stay between mild cases (grades of mamushi bites I and II) (P = 0.77). Our results show that antivenom is effective in reducing the length of hospital stay in patients with severe mamushi bites.